首页> Nature communications> Extracellular nanovesicles for packaging of CRISPR-Cas9 protein and sgRNA to induce therapeutic exon skipping.

Extracellular nanovesicles for packaging of CRISPR-Cas9 protein and sgRNA to induce therapeutic exon skipping.

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第一作者： Peter,Gee

第一单位： Center for iPS Cell Research and Application (CiRA), Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan.;Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University, Yoshida Ushinomiya-cho, Sakyo-ku, Kyoto, 606-8507, Japan.;Takeda-CiRA Joint Program (T-CiRA), Fujisawa, Kanagawa, Japan.

作者： Peter,Gee ^[1] ; Mandy S Y,Lung ^[2] ; Yuya,Okuzaki ^[2] ; Noriko,Sasakawa ^[2] ; Takahiro,Iguchi ^[2] ; Yukimasa,Makita ^[3] ; Hiroyuki,Hozumi ^[3] ; Yasutomo,Miura ^[2] ; Lucy F,Yang ^[2] ; Mio,Iwasaki ^[2] ; Xiou H,Wang ^[2] ; Matthew A,Waller ^[2] ; Nanako,Shirai ^[2] ; Yasuko O,Abe ^[2] ; Yoko,Fujita ^[4] ; Kei,Watanabe ^[2] ; Akihiro,Kagita ^[2] ; Kumiko A,Iwabuchi ^[5] ; Masahiko,Yasuda ^[6] ; Huaigeng,Xu ^[2] ; Takeshi,Noda ^[4] ; Jun,Komano ^[7] ; Hidetoshi,Sakurai ^[2] ; Naoto,Inukai ^[3] ; Akitsu,Hotta ^[8]

作者单位： Center for iPS Cell Research and Application (CiRA), Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan.;Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University, Yoshida Ushinomiya-cho, Sakyo-ku, Kyoto, 606-8507, Japan.;Takeda-CiRA Joint Program (T-CiRA), Fujisawa, Kanagawa, Japan. ^[1] Center for iPS Cell Research and Application (CiRA), Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan. ^[2] Takeda-CiRA Joint Program (T-CiRA), Fujisawa, Kanagawa, Japan.;T-CiRA Discovery, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa, 251-8555, Japan. ^[3] Laboratory of Ultrastructural Virology, Institute for Frontier Life and Medical Sciences, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan. ^[4] Center for iPS Cell Research and Application (CiRA), Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan.;Takeda-CiRA Joint Program (T-CiRA), Fujisawa, Kanagawa, Japan. ^[5] Pathology Analysis Center, Central Institute for Experimental Animals, Kawasaki, Kanagawa, 210-0821, Japan. ^[6] Department of Clinical Laboratory, Nagoya Medical Center, 1-1 4-chome, Sannomaru, Naka-ku, Nagoya, 460-0001, Japan.;Department of Infection Control, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka, 569-1041, Japan. ^[7] Center for iPS Cell Research and Application (CiRA), Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan. akitsu.hotta@cira.kyoto-u.ac.jp.;Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University, Yoshida Ushinomiya-cho, Sakyo-ku, Kyoto, 606-8507, Japan. akitsu.hotta@cira.kyoto-u.ac.jp.;Takeda-CiRA Joint Program (T-CiRA), Fujisawa, Kanagawa, Japan. akitsu.hotta@cira.kyoto-u.ac.jp. ^[8]