CAS9 is a genome mutator by directly disrupting DNA-PK dependent DNA repair pathway.

导出 OA

翻译打印收藏纠错

作者： Shuxiang,Xu ^[1] ; Jinchul,Kim ^[2] ; Qingshuang,Tang ^[3] ; Qu,Chen ^[1] ; Jingfeng,Liu ^[1] ; Yang,Xu ^[2] ; Xuemei,Fu ^[1]

作者单位： Cancer Research Institute, Guangdong Provincial Key Laboratory of Cancer Immunotherapy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China. ^[1] The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518033, China. ^[2] Division of Biological Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA. ^[3] Cancer Research Institute, Guangdong Provincial Key Laboratory of Cancer Immunotherapy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China. yangxu@ucsd.edu. ^[4] The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518033, China. yangxu@ucsd.edu. ^[5] Division of Biological Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA. yangxu@ucsd.edu. ^[6] Shenzhen Children's Hospital, Shenzhen, 518026, China. ^[7]

关键词 CAS9 DNA double-stranded breaks DNA repair DNA-PK genetic instability

主题词细胞系(Cell Line);DNA(DNA);DNA修复(DNA Repair);人类(Humans);蛋白激酶类(Protein Kinases)

DOI 10.1007/s13238-020-00699-6

PMID 32170574

发布时间 2020-12-31

翻译满意度评价：

准确一般字义偏差语意偏离译文作用小提交