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Interaction of SHP-2 SH2 domains with PD-1 ITSM induces PD-1 dimerization and SHP-2 activation.

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第一作者： Nikolaos,Patsoukis

第一单位： Division of Hematology-Oncology Beth Israel Deaconess Medical Center, Boston, MA, 02215, USA.;Department of Medicine Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.

作者： Nikolaos,Patsoukis ^[1] ; Jonathan S,Duke-Cohan ^[2] ; Apoorvi,Chaudhri ^[3] ; Halil-Ibrahim,Aksoylar ^[1] ; Qi,Wang ^[1] ; Asia,Council ^[1] ; Anders,Berg ^[4] ; Gordon J,Freeman ^[2] ; Vassiliki A,Boussiotis ^[5]

作者单位： Division of Hematology-Oncology Beth Israel Deaconess Medical Center, Boston, MA, 02215, USA.;Department of Medicine Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA. ^[1] Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, 02215, USA. ^[2] Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, 02215, USA.;MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX, 77030, USA. ^[3] Department of Pathology Beth Israel Deaconess Cancer Center, Harvard Medical School, Boston, MA, 02215, USA.;Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA. ^[4] Division of Hematology-Oncology Beth Israel Deaconess Medical Center, Boston, MA, 02215, USA. vboussio@bidmc.harvard.edu.;Department of Medicine Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA. vboussio@bidmc.harvard.edu. ^[5]

医学主题词动物(Animals);COS细胞(COS Cells);酶激活(Enzyme Activation);HEK293细胞(HEK293 Cells);人类(Humans);Jurkat细胞(Jurkat Cells);小鼠, 基因敲除(Mice, Knockout);磷酰化(Phosphorylation);蛋白质结合(Protein Binding);蛋白质多聚化(Protein Multimerization);蛋白质酪氨酸磷酸酶, 非受体11型(Protein Tyrosine Phosphatase, Non-Receptor Type 11);原癌基因蛋白质c-fyn(Proto-Oncogene Proteins c-fyn);T淋巴细胞(T-Lymphocytes);src同源域(src Homology Domains)

DOI 10.1038/s42003-020-0845-0

PMID 32184441

发布时间 2025-01-04

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Communications biology

2020年3卷1期

128页

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Communications biology

2020年3卷1期

128页

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Interaction of SHP-2 SH2 domains with PD-1 ITSM induces PD-1 dimerization and SHP-2 activation.

Communications biology

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Interaction of SHP-2 SH2 domains with PD-1 ITSM induces PD-1 dimerization and SHP-2 activation.

Communications biology

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Communications biology

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