Benzothiazolyl Ureas are Low Micromolar and Uncompetitive Inhibitors of 17β-HSD10 with Implications to Alzheimer's Disease Treatment.

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作者： Monika,Schmidt ^[1] ; Ondrej,Benek ^[1] ; Lucie,Vinklarova ^[2] ; Martina,Hrabinova ^[3] ; Lucie,Zemanova ^[1] ; Matej,Chribek ^[2] ; Vendula,Kralova ^[2] ; Lukas,Hroch ^[4] ; Rafael,Dolezal ^[1] ; Antonin,Lycka ^[5] ; Lukas,Prchal ^[5] ; Daniel,Jun ^[2] ; Laura,Aitken ^[1] ; Frank,Gunn-Moore ^[2] ; Kamil,Kuca ^[1] ; Kamil,Musilek ^[2]

作者单位： University of Hradec Kralove, Faculty of Science, Department of Chemistry, Rokitanskeho 62, 500 03 Hradec Kralove, Czech Republic. ^[1] University Hospital Hradec Kralove, Biomedical Research Centre, Sokolska 581, 500 05 Hradec Kralove, Czech Republic. ^[2] National Institute of Mental Health, Topolova 748, 250 67 Klecany, Czech Republic. ^[3] University of Defence, Faculty of Military Health Sciences, Department of Toxicology and Military Pharmacy, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic. ^[4] Charles University in Prague, Faculty of Pharmacy in Hradec Kralove, Department of Pharmaceutical Chemistry and Drug Control, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic. ^[5] University of St. Andrews, School of Biology, Medical and Biological Science Building, North Haugh, St. Andrews KY16 9TF, UK. ^[6]

关键词 17β-hydroxysteroid dehydrogenase type 10 ABAD Alzheimer’s disease benzothiazole inhibitor neurodegeneration