Gene signatures in peripheral blood immune cells related to insulin resistance and low tyrosine metabolism define a sub-type of depression with high CRP and anhedonia.

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作者： Mandakh,Bekhbat ^[1] ; Michael T,Treadway ^[2] ; David R,Goldsmith ^[3] ; Bobbi J,Woolwine ^[3] ; Ebrahim,Haroon ^[4] ; Andrew H,Miller ^[4] ; Jennifer C,Felger ^[4]

作者单位： Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA 30322, USA. Electronic address: mbekhba@emory.edu. ^[1] Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA 30322, USA; The Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA; Department of Psychology, Emory University, Atlanta, GA, USA. ^[2] Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA 30322, USA. ^[3] Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA 30322, USA; The Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA. ^[4]

关键词 Anhedonia C-reactive protein Depression Dopamine Gene expression Glucose metabolism Inflammation Insulin Tyrosine

主题词 C反应蛋白质(C-Reactive Protein);抑郁(Depression);抑郁症, 更年期(Depressive Disorder, Major);人类(Humans);胰岛素抗药性(Insulin Resistance);磷酸肌醇3-激酶类(Phosphatidylinositol 3-Kinases);酪氨酸(Tyrosine)

DOI 10.1016/j.bbi.2020.03.015

PMID 32198016

发布时间 2021-08-02

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