Differential antitumor activity of compounds targeting the ubiquitin-proteasome machinery in gastrointestinal stromal tumor (GIST) cells.-论文-万方医学网

第一作者： Jessica L,Rausch

第一单位： Cancer Therapeutics Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.

作者： Jessica L,Rausch ^[1] ; Areej A,Ali ^[1] ; Donna M,Lee ^[1] ; Yemarshet K,Gebreyohannes ^[2] ; Keith R,Mehalek ^[1] ; Aya,Agha ^[1] ; Sneha S,Patil ^[1] ; Yanis,Tolstov ^[3] ; Jasmien,Wellens ^[2] ; Harbir S,Dhillon ^[1] ; Kathleen R,Makielski ^[1] ; Maria,Debiec-Rychter ^[4] ; Patrick,Schöffski ^[2] ; Agnieszka,Wozniak ^[2] ; Anette,Duensing ^[5]

作者单位： Cancer Therapeutics Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA. ^[1] Departments of Oncology and General Medical Oncology, University Hospitals Leuven and KU Leuven Cancer Institute, Leuven, Belgium. ^[2] Molecular Urooncology, University of Heidelberg School of Medicine, Heidelberg, Germany. ^[3] Department of Human Genetics, University Hospitals Leuven and KU Leuven, Leuven, Belgium. ^[4] Cancer Therapeutics Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA. aduensin@pitt.edu. ^[5] Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. aduensin@pitt.edu. ^[6]

主题词动物(Animals);抗肿瘤药(Antineoplastic Agents);细胞凋亡(Apoptosis);硼化合物(Boron Compounds);硼酸化物(Boronic Acids);细胞系, 肿瘤(Cell Line, Tumor);抗药性, 肿瘤(Drug Resistance, Neoplasm);女(雌)性(Female);胃肠道间质肿瘤(Gastrointestinal Stromal Tumors);甘氨酸(Glycine);人类(Humans);男(雄)性(Male);小鼠(Mice);小鼠, 裸(Mice, Nude);寡肽类(Oligopeptides);蛋白酶体内肽酶复合物(Proteasome Endopeptidase Complex);蛋白激酶抑制剂(Protein Kinase Inhibitors);原癌基因蛋白质类c-kit(Proto-Oncogene Proteins c-kit);信号传导(Signal Transduction);苏氨酸(Threonine);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)

DOI 10.1038/s41598-020-62088-7

PMID 32198455

发布时间 2021-03-20

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Differential antitumor activity of compounds targeting the ubiquitin-proteasome machinery in gastrointestinal stromal tumor (GIST) cells.

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Differential antitumor activity of compounds targeting the ubiquitin-proteasome machinery in gastrointestinal stromal tumor (GIST) cells.

Scientific reports

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Scientific reports

相关期刊

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