Enhanced efficacy of a multi-epitope vaccine for type A and O foot‑and-mouth disease virus by fusing multiple epitopes with Mycobacterium tuberculosis heparin-binding hemagglutinin (HBHA), a novel TLR4 agonist.

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作者： Yao,Lei ^[1] ; Junjun,Shao ^[1] ; Feifei,Ma ^[2] ; Chenglin,Lei ^[2] ; Huiyun,Chang ^[3] ; Yongguang,Zhang ^[4]

作者单位： State Key Laboratory of Veterinary Etiological Biology, OIE/National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, Gansu, China; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu Province, 225009, China. ^[1] State Key Laboratory of Veterinary Etiological Biology, OIE/National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, Gansu, China. ^[2] State Key Laboratory of Veterinary Etiological Biology, OIE/National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, Gansu, China; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu Province, 225009, China. Electronic address: changhuiyun@caas.cn. ^[3] State Key Laboratory of Veterinary Etiological Biology, OIE/National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, Gansu, China; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu Province, 225009, China. Electronic address: zhangyongguang@caas.cn. ^[4]

关键词 FMDV HBHA Multi-epitope vaccine TLR4 agonist

主题词佐剂, 免疫(Adjuvants, Immunologic);动物(Animals);抗体, 中和(Antibodies, Neutralizing);抗体, 病毒(Antibodies, Viral);树突细胞(Dendritic Cells);表位, B淋巴细胞(Epitopes, B-Lymphocyte);表位, T淋巴细胞(Epitopes, T-Lymphocyte);女(雌)性(Female);口蹄疫(Foot-and-Mouth Disease);口蹄疫病毒(Foot-and-Mouth Disease Virus);免疫, 细胞(Immunity, Cellular);外源凝集素类(Lectins);小鼠(Mice);结核分枝杆菌(Mycobacterium tuberculosis);重组融合蛋白质类(Recombinant Fusion Proteins);Toll样受体4(Toll-Like Receptor 4);疫苗, 亚单位(Vaccines, Subunit);病毒疫苗(Viral Vaccines)

DOI 10.1016/j.molimm.2020.02.018

PMID 32199211

发布时间 2020-07-13

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Molecular immunology

2020年121卷

118-126页

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Enhanced efficacy of a multi-epitope vaccine for type A and O foot‑and-mouth disease virus by fusing multiple epitopes with Mycobacterium tuberculosis heparin-binding hemagglutinin (HBHA), a novel TLR4 agonist.

Molecular immunology

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Molecular immunology

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Enhanced efficacy of a multi-epitope vaccine for type A and O foot‑and-mouth disease virus by fusing multiple epitopes with Mycobacterium tuberculosis heparin-binding hemagglutinin (HBHA), a novel TLR4 agonist.

Molecular immunology

相似文献

Molecular immunology

相关期刊

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