Modulation of the cardiac sodium channel Na<sub>V</sub>1.5 peak and late currents by NAD<sup>+</sup> precursors.

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第一作者： Daniel S,Matasic

第一单位： Division of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, United States of America; Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, IA, United States of America; Department of Molecular Physiology and Biophysics, University of Iowa Carver College of Medicine, Iowa City, IA, United States of America.

作者： Daniel S,Matasic ^[1] ; Jin-Young,Yoon ^[2] ; Jared M,McLendon ^[2] ; Haider,Mehdi ^[2] ; Mark S,Schmidt ^[3] ; Alexander M,Greiner ^[2] ; Pravda,Quinones ^[2] ; Gina M,Morgan ^[2] ; Ryan L,Boudreau ^[2] ; Kaikobad,Irani ^[2] ; Charles,Brenner ^[3] ; Barry,London ^[4]

作者单位： Division of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, United States of America; Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, IA, United States of America; Department of Molecular Physiology and Biophysics, University of Iowa Carver College of Medicine, Iowa City, IA, United States of America. ^[1] Division of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, United States of America; Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, IA, United States of America. ^[2] Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, IA, United States of America; Department of Biochemistry, University of Iowa Carver College of Medicine, Iowa City, IA, United States of America. ^[3] Division of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, United States of America; Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, IA, United States of America; Department of Molecular Physiology and Biophysics, University of Iowa Carver College of Medicine, Iowa City, IA, United States of America. Electronic address: barry-london@uiowa.edu. ^[4]

关键词 Acetylation Arrhythmia Cardiac Sodium Channel (Na(V)1.5, SCN5A)Metabolic regulation NAD(+)/NADH Nicotinamide Nicotinamide riboside Sirtuins