Function-based high-throughput screening for antibody antagonists and agonists against G protein-coupled receptors.

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作者： Huanhuan,Ren ^[1] ; Jian,Li ^[2] ; Ning,Zhang ^[1] ; Liaoyuan A,Hu ^[1] ; Yingli,Ma ^[1] ; Philip,Tagari ^[1] ; Jianqing,Xu ^[3] ; Mei-Yun,Zhang ^[4]

作者单位： Amgen Research, Amgen Asia R&D Center, Amgen Biopharmaceutical R&D (Shanghai) Co., Ltd., 13th Floor, Building No. 2, 4560 Jinke Road, Zhangjiang, Shanghai, 201210, China. ^[1] Shanghai Public Health Clinical Center, Institutes of Biomedical Sciences, Fudan University, PI's Office IV, Scientific Research Center Building, 2901 Caolang Road, Jin Shan District, Shanghai, 201508, P. R. China. ^[2] Amgen Research, Therapeutic Discovery, Amgen Inc., One Amgen Center Dr, Thousand Oaks, CA, 91320, USA. ^[3] Shanghai Public Health Clinical Center, Institutes of Biomedical Sciences, Fudan University, PI's Office IV, Scientific Research Center Building, 2901 Caolang Road, Jin Shan District, Shanghai, 201508, P. R. China. xujianqing@shphc.org.cn. ^[4] Amgen Research, Amgen Asia R&D Center, Amgen Biopharmaceutical R&D (Shanghai) Co., Ltd., 13th Floor, Building No. 2, 4560 Jinke Road, Zhangjiang, Shanghai, 201210, China. meiyunz@amgen.com. ^[5]

主题词动物(Animals);抗体(Antibodies);CHO细胞(CHO Cells);细胞系, 肿瘤(Cell Line, Tumor);仓鼠属(Cricetulus);药物发现(Drug Discovery);流式细胞术(Flow Cytometry);基因, 报告(Genes, Reporter);HEK293细胞(HEK293 Cells);高通量筛选分析(High-Throughput Screening Assays);人类(Humans);杂交瘤(Hybridomas);信号传导(Signal Transduction)

DOI 10.1038/s42003-020-0867-7

PMID 32218528

发布时间 2021-06-15

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Communications biology

2020年3卷1期

146页

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Function-based high-throughput screening for antibody antagonists and agonists against G protein-coupled receptors.

Communications biology

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Function-based high-throughput screening for antibody antagonists and agonists against G protein-coupled receptors.

Communications biology

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Communications biology

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