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Phagocytosis of Wnt inhibitor SFRP4 by late wound macrophages drives chronic Wnt activity for fibrotic skin healing.

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第一作者： Denise,Gay

第一单位： CEA/DRF/IBFJ/iRCM/LRTS, 92265 Fontenay-aux-Roses cedex, France.;Inserm U1074, 92265 Fontenay-aux-Roses cedex, France.

作者： Denise,Gay ^[1] ; Giulia,Ghinatti ^[2] ; Christian F,Guerrero-Juarez ^[3] ; Rubén A,Ferrer ^[4] ; Federica,Ferri ^[2] ; Chae Ho,Lim ^[5] ; Shohei,Murakami ^[2] ; Nathalie,Gault ^[2] ; Vilma,Barroca ^[2] ; Isabelle,Rombeau ^[6] ; Philippe,Mauffrey ^[7] ; Lamya,Irbah ^[7] ; Elsa,Treffeisen ^[8] ; Sandra,Franz ^[9] ; Alexandre,Boissonnas ^[10] ; Christophe,Combadière ^[10] ; Mayumi,Ito ^[5] ; Maksim V,Plikus ^[3] ; Paul-Henri,Romeo ^[2]

作者单位： CEA/DRF/IBFJ/iRCM/LRTS, 92265 Fontenay-aux-Roses cedex, France.;Inserm U1074, 92265 Fontenay-aux-Roses cedex, France. ^[1] CEA/DRF/IBFJ/iRCM/LRTS, 92265 Fontenay-aux-Roses cedex, France.;Inserm U1074, 92265 Fontenay-aux-Roses cedex, France.;Université Paris-Diderot, Paris 7, France.;Université Paris-Sud, Paris 11, France. ^[2] Department of Developmental and Cell Biology, Sue and Bill Gross Stem Cell Research Center, NSF-Simons Center for Multiscale Cell Fate Research, Center for Complex Biological Systems, University of California, Irvine, Irvine, CA 92697, USA. ^[3] Department of Dermatology, University Leipzig Medical Center, Leipzig, Germany. ^[4] Ronald O. Perelman Department of Dermatology and Cell Biology, School of Medicine, New York University, New York, NY 10016, USA. ^[5] Charles River Laboratories, 169 Bois des Oncins, 69210 Saint-Germain-Nuelles, France. ^[6] CEA/DRF/IBFJ/iRCM/LRTS, 92265 Fontenay-aux-Roses cedex, France.;Inserm U1074, 92265 Fontenay-aux-Roses cedex, France.;Université Paris-Diderot, Paris 7, France. ^[7] Department of Pediatrics, Cohen Children's Medical Center Northwell Health, New Hyde Park, NY 11040, USA. ^[8] Department of Dermatology, University Leipzig Medical Center, Leipzig, Germany.;DFG-German Research Council Transregio 67, Leipzig-Dresden, Germany. ^[9] Sorbonne Université, Inserm, CNRS, Centre d'Immunologie et des Maladies Infectieuses, Cimi-Paris, F-75013, Paris, France. ^[10]

医学主题词成纤维细胞(Fibroblasts);纤维化(Fibrosis);人类(Humans);巨噬细胞(Macrophages);吞噬作用(Phagocytosis);原癌基因蛋白质类(Proto-Oncogene Proteins);皮肤(Skin);Wnt蛋白质类(Wnt Proteins);伤口愈合(Wound Healing)

DOI 10.1126/sciadv.aay3704

PMID 32219160

发布时间 2025-01-04

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Phagocytosis of Wnt inhibitor SFRP4 by late wound macrophages drives chronic Wnt activity for fibrotic skin healing.

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Phagocytosis of Wnt inhibitor SFRP4 by late wound macrophages drives chronic Wnt activity for fibrotic skin healing.

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