Self DNA perpetuates IPF lung fibroblast senescence in a cGAS-dependent manner.

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作者： Michael,Schuliga ^[1] ; Jane,Read ^[2] ; Kaj E C,Blokland ^[1] ; David W,Waters ^[2] ; Janette,Burgess ^[1] ; Cecilia,Prêle ^[2] ; Steven E,Mutsaers ^[3] ; Jade,Jaffar ^[4] ; Glen,Westall ^[1] ; Andrew,Reid ^[2] ; Allen,James ^[3] ; Christopher,Grainge ^[5] ; Darryl A,Knight ^[6]

作者单位： School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW, Australia. ^[1] Hunter Medical Research Institute, New Lambton Heights, NSW, Australia. ^[2] University of Groningen, University Medical Center Groningen, Department of Pathology and Medical Biology, Groningen Research Institute of Asthma and COPD and KOLFF Institute, Netherlands. ^[3] National Health and Medical Research Council Centre of Research Excellence in Pulmonary Fibrosis, Sydney, NSW, Australia. ^[4] Institute for Respiratory Health, University of Western Australia, Nedlands, WA, Australia. ^[5] Centre for Cell Therapy and Regenerative Medicine, School of Biomedical Sciences, University of Western Australia, Crawley, WA, Australia. ^[6] Ear Science Institute Australia, Subiaco, WA, Australia. ^[7] Allergy, Immunology and Respiratory Medicine, Alfred Hospital, Prahran, Victoria, Australia. ^[8] School of Medicine and Public Health, University of Newcastle, Callaghan, NSW, Australia. ^[9] John Hunter Hospital, Newcastle, NSW, Australia. ^[10] Providence Health Care Research Institute, Vancouver, British Columbia, Canada. ^[11]

关键词 GMP-AMP synthase (cGAS)cGAMP mtDNA pulmonary fibrosis senescence