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首页> Research in veterinary science> The PERK/eIF2α/ATF4/CHOP pathway plays a role in regulating monocrotaline-induced endoplasmic reticulum stress in rat liver.

The PERK/eIF2α/ATF4/CHOP pathway plays a role in regulating monocrotaline-induced endoplasmic reticulum stress in rat liver.

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作者： Yazhou,Guo ^[1] ; Rong,Guo ^[1] ; Yongxia,Su ^[1] ; Jingjing,Fu ^[1] ; Shuai,Wang ^[1] ; Yezi,Kong ^[1] ; Chenchen,Wu ^[1] ; Jianguo,Wang ^[1] ; Chenjian,Tan ^[2] ; Chonghui,Mo ^[3] ; Baoyu,Zhao ^[4]

作者单位： College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi 712100, China; Institute of Poisonous Plants in Western China, Northwest A&F University, Yangling, Shaanxi 712100, China. ^[1] Department of Biotechnology, Guizhou Medical University, Guiyang, Guizhou 550004, China. ^[2] College of Agriculture and Animal Husbandry, Qinghai University, Xining, Qinghai 810016, China. ^[3] College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi 712100, China; Institute of Poisonous Plants in Western China, Northwest A&F University, Yangling, Shaanxi 712100, China. Electronic address: zhaobaoyu12005@nwafu.edu.cn. ^[4]

关键词 Endoplasmic reticulum stress Hepatotoxicity Monocrotaline PERK-eIF2a-ATF4-CHOP pathway

主题词转录激活因子4(Activating Transcription Factor 4);动物(Animals);真核细胞起始因子2(Eukaryotic Initiation Factor-2);肝(Liver);男(雄)性(Male);野百合碱(Monocrotaline);大鼠(Rats);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);转录因子CHOP(Transcription Factor CHOP);eIF-2激酶(eIF-2 Kinase)

DOI 10.1016/j.rvsc.2020.03.021

PMID 32224353

发布时间 2020-09-10

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