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首页> Materials science & engineering. C, Materials for biological applications> Injectable in situ forming nanogel: A hybrid Alginate-NLC formulation extends bupivacaine anesthetic effect.

Injectable in situ forming nanogel: A hybrid Alginate-NLC formulation extends bupivacaine anesthetic effect.

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作者： Gustavo H,Rodrigues da Silva ^[1] ; Gabriela,Geronimo ^[1] ; Lígia N M,Ribeiro ^[1] ; Viviane A,Guilherme ^[1] ; Ludmilla David,de Moura ^[1] ; André L,Bombeiro ^[2] ; Juliana Damasceno,Oliveira ^[1] ; Márcia C,Breitkreitz ^[3] ; Eneida,de Paula ^[4]

作者单位： Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas - UNICAMP, Campinas, São Paulo, Brazil. ^[1] Department of Structural and Functional Biology, Institute of Biology, University of Campinas - UNICAMP, Campinas, São Paulo, Brazil. ^[2] Department of Analytical Chemistry, Institute of Chemistry, UNICAMP, Campinas, São Paulo, Brazil. ^[3] Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas - UNICAMP, Campinas, São Paulo, Brazil. Electronic address: depaula@unicamp.br. ^[4]

关键词 Alginate Biopolymers Bupivacaine Drug delivery Hybrid formulation Lipid nanoparticles

主题词藻酸盐(Alginates);麻醉药, 局部(Anesthetics, Local);动物(Animals);布比卡因(Bupivacaine);药物植入物(Drug Implants);凝胶类(Gels);男(雄)性(Male);纳米结构(Nanostructures);大鼠(Rats);大鼠, Wistar(Rats, Wistar)

DOI 10.1016/j.msec.2019.110608

PMID 32228992

发布时间 2020-12-25

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Materials science & engineering. C, Materials for biological applications

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