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A randomized proof-of-mechanism trial applying the 'fast-fail' approach to evaluating κ-opioid antagonism as a treatment for anhedonia.

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第一作者： Andrew D,Krystal

第一单位： Department of Psychiatry, University of California, San Francisco, San Francisco, CA, USA. andrew.krystal@ucsf.edu.;Departments of Psychiatry and Behavioral Sciences and Radiology, Duke University School of Medicine, Durham, NC, USA. andrew.krystal@ucsf.edu.

作者： Andrew D,Krystal ^[1] ; Diego A,Pizzagalli ^[2] ; Moria,Smoski ^[3] ; Sanjay J,Mathew ^[4] ; John,Nurnberger ^[5] ; Sarah H,Lisanby ^[6] ; Dan,Iosifescu ^[7] ; James W,Murrough ^[8] ; Hongqiu,Yang ^[9] ; Richard D,Weiner ^[3] ; Joseph R,Calabrese ^[10] ; Gerard,Sanacora ^[11] ; Gretchen,Hermes ^[11] ; Richard S E,Keefe ^[3] ; Allen,Song ^[3] ; Wayne,Goodman ^[12] ; Steven T,Szabo ^[13] ; Alexis E,Whitton ^[14] ; Keming,Gao ^[10] ; William Z,Potter ^[6]

作者单位： Department of Psychiatry, University of California, San Francisco, San Francisco, CA, USA. andrew.krystal@ucsf.edu.;Departments of Psychiatry and Behavioral Sciences and Radiology, Duke University School of Medicine, Durham, NC, USA. andrew.krystal@ucsf.edu. ^[1] McLean Hospital, Harvard Medical School, Belmont, MA, USA. ^[2] Departments of Psychiatry and Behavioral Sciences and Radiology, Duke University School of Medicine, Durham, NC, USA. ^[3] Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA.;Michael E. Debakey VA Medical Center, Houston, TX, USA. ^[4] Departments of Psychiatry and Neurobiology, Indiana University School of Medicine, Indianapolis, IN, USA. ^[5] National Institute of Mental Health, Bethesda, MD, USA. ^[6] Department of Psychiatry, New York University School of Medicine, New York, NY, USA. ^[7] Department of Psychiatry and Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA. ^[8] Duke Clinical Research Institute, Durham, NC, USA. ^[9] Department of Psychiatry, Case Western Reserve School of Medicine, Cleveland, OH, USA. ^[10] Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA. ^[11] Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA. ^[12] Departments of Psychiatry and Behavioral Sciences and Radiology, Duke University School of Medicine, Durham, NC, USA.;Durham VA Health Care System, Durham, NC, USA. ^[13] McLean Hospital, Harvard Medical School, Belmont, MA, USA.;The University of Sydney, Sydney, New South Wales, Australia. ^[14]