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首页> Cell reports> Targeting the Extrinsic Pathway of Hepatocyte Apoptosis Promotes Clearance of Plasmodium Liver Infection.

Targeting the Extrinsic Pathway of Hepatocyte Apoptosis Promotes Clearance of Plasmodium Liver Infection.

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作者： Gregor,Ebert ^[1] ; Sash,Lopaticki ^[2] ; Matthew T,O'Neill ^[2] ; Ryan W J,Steel ^[1] ; Marcel,Doerflinger ^[1] ; Pravin,Rajasekaran ^[1] ; Annie S P,Yang ^[1] ; Sara,Erickson ^[1] ; Lisa,Ioannidis ^[1] ; Philip,Arandjelovic ^[1] ; Liana,Mackiewicz ^[2] ; Cody,Allison ^[1] ; John,Silke ^[1] ; Marc,Pellegrini ^[3] ; Justin A,Boddey ^[4]

作者单位： The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia. ^[1] The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia. ^[2] The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia. Electronic address: pellegrini@wehi.edu.au. ^[3] The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia. Electronic address: boddey@wehi.edu.au. ^[4]

关键词 IAP antagonist Plasmodium SMAC mimetic T cells antibodies birinapant cIAP immunity inhibitor of apoptosis proteins protection

主题词投药, 口服(Administration, Oral);动物(Animals);细胞凋亡(Apoptosis);生物利用度(Biological Availability);半胱氨酸天冬氨酸蛋白酶3(Caspase 3);蚊科(Culicidae);二肽类(Dipeptides);肝细胞(Hepatocytes);免疫(Immunity);吲哚类(Indoles);凋亡抑制蛋白质类(Inhibitor of Apoptosis Proteins);生命周期各时期(Life Cycle Stages);肝(Liver);疟疾(Malaria);疟原虫属(Plasmodium);原虫蛋白质类(Protozoan Proteins);孢子体(Sporozoites);噻唑类(Thiazoles);肿瘤坏死因子α(Tumor Necrosis Factor-alpha)

DOI 10.1016/j.celrep.2020.03.032

PMID 32234472

发布时间 2021-03-26

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Cell reports

Cell reports

2020年30卷13期

4343-4354.e4页

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