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Cysteine depletion induces pancreatic tumor ferroptosis in mice.

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作者单位: Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA. [1] Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA. [2] Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA. [3] Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA. [4] Klinikum rechts der Isar, II, Medizinische Klinik, Technische Universität München, 81675, Munich, Germany. [5] Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA. [6] Waitt Advanced Biophotonics Center, Salk Institute for Biological Studies, La Jolla, CA 92037, USA. [7] Michigan Regional Comprehensive Metabolomics Resource Core, University of Michigan, Ann Arbor, MI 48105, USA. [8] Departments of Biological Sciences and Chemistry, Columbia University, New York, NY 10027, USA. [9] Department of Chemical Engineering, University of Texas at Austin, Austin, TX 78712, USA. [10] Institute for Cancer Genetics, Columbia University Medical Center, New York, NY 10032, USA. [11] Department of Pathology, Columbia University Medical Center, New York, NY 10032, USA. [12] Department of Pathology, University of California, San Francisco, CA 94143, USA. [13] Salvo Therapeutics, San Francisco, CA 94117, USA. [14] Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA. [15] Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI 48109, USA. [16] Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA. kenolive@columbia.edu. [17]
DOI 10.1126/science.aaw9872
PMID 32241947
发布时间 2021-05-13
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