Squalenyl Hydrogen Sulfate Nanoparticles for Simultaneous Delivery of Tobramycin and an Alkylquinolone Quorum Sensing Inhibitor Enable the Eradication of P. aeruginosa Biofilm Infections.

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第一作者： Duy-Khiet,Ho

第一单位： Helmholtz Institute for Pharmaceutical Research Saarland, Helmholtz Center for Infection Research, 66123, Saarbrücken, Germany.;Department of Pharmacy, Saarland University, 66123, Saarbrücken, Germany.;Current address: Department of Bioengineering, School of Medicine, University of Washington, Seattle, WA, 98195, USA.

作者： Duy-Khiet,Ho ^[1] ; Xabier,Murgia ^[2] ; Chiara,De Rossi ^[3] ; Rebekka,Christmann ^[4] ; Antonio G,Hüfner de Mello Martins ^[3] ; Marcus,Koch ^[5] ; Anastasia,Andreas ^[6] ; Jennifer,Herrmann ^[6] ; Rolf,Müller ^[7] ; Martin,Empting ^[7] ; Rolf W,Hartmann ^[7] ; Didier,Desmaele ^[8] ; Brigitta,Loretz ^[3] ; Patrick,Couvreur ^[8] ; Claus-Michael,Lehr ^[4]

作者单位： Helmholtz Institute for Pharmaceutical Research Saarland, Helmholtz Center for Infection Research, 66123, Saarbrücken, Germany.;Department of Pharmacy, Saarland University, 66123, Saarbrücken, Germany.;Current address: Department of Bioengineering, School of Medicine, University of Washington, Seattle, WA, 98195, USA. ^[1] Helmholtz Institute for Pharmaceutical Research Saarland, Helmholtz Center for Infection Research, 66123, Saarbrücken, Germany.;Department of Pharmacy, Saarland University, 66123, Saarbrücken, Germany.;Current address: Kusudama Therapeutics, Parque Científico y Tecnológico de Gipuzkoa, 20014, Donostia-San Sebastián, Spain. ^[2] Helmholtz Institute for Pharmaceutical Research Saarland, Helmholtz Center for Infection Research, 66123, Saarbrücken, Germany. ^[3] Helmholtz Institute for Pharmaceutical Research Saarland, Helmholtz Center for Infection Research, 66123, Saarbrücken, Germany.;Department of Pharmacy, Saarland University, 66123, Saarbrücken, Germany. ^[4] INM-Leibniz Institute for New Materials, 66123, Saarbrücken, Germany. ^[5] Helmholtz Institute for Pharmaceutical Research Saarland, Helmholtz Center for Infection Research, 66123, Saarbrücken, Germany.;German Centre for Infection Research (DZIF), Partner Site Hannover-Braunschweig, 66123, Saarbrücken, Germany. ^[6] Helmholtz Institute for Pharmaceutical Research Saarland, Helmholtz Center for Infection Research, 66123, Saarbrücken, Germany.;German Centre for Infection Research (DZIF), Partner Site Hannover-Braunschweig, 66123, Saarbrücken, Germany.;Department of Pharmacy, Saarland University, 66123, Saarbrücken, Germany. ^[7] Faculté de Pharmacie, Institut Galien Paris Sud, Université Paris-Saclay, UMR CNRS 8612, 92296, Châtenay-Malabry, France. ^[8]

关键词 Pseudomonas aeruginosa biofilms drug delivery quorum sensing inhibitors tobramycin