NPM1 upregulates the transcription of PD-L1 and suppresses T cell activity in triple-negative breast cancer.
第一作者:
Ge,Qin
第一单位:
Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, China.;The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
作者:
医学主题词
成年人(Adult);老年人(Aged);动物(Animals);抗肿瘤联合化疗方案(Antineoplastic Combined Chemotherapy Protocols);乳房(Breast);细胞系, 肿瘤(Cell Line, Tumor);DNA结合蛋白质类(DNA-Binding Proteins);疾病模型, 动物(Disease Models, Animal);药物协同作用(Drug Synergism);女(雌)性(Female);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);基因敲低技术(Gene Knockdown Techniques);人类(Humans);Kaplan-Meiers评估(Kaplan-Meier Estimate);淋巴细胞, 肿瘤浸润(Lymphocytes, Tumor-Infiltrating);小鼠(Mice);中年人(Middle Aged);核蛋白质类(Nuclear Proteins);酞嗪类(Phthalazines);哌嗪类(Piperazines);预后(Prognosis);启动区, 遗传(Promoter Regions, Genetic);T淋巴细胞(T-Lymphocytes);组织阵列分析(Tissue Array Analysis);转录激活(Transcriptional Activation);增量调节(Up-Regulation)
DOI
10.1038/s41467-020-15364-z
PMID
32245950
发布时间
2021-12-04
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