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Design, synthesis and biological evaluation of spiropyrazolopyridone derivatives as potent dengue virus inhibitors.

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第一作者： Jimin,Xu

第一单位： Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX 77555, United States.

作者： Jimin,Xu ^[1] ; Xuping,Xie ^[2] ; Haiying,Chen ^[1] ; Jing,Zou ^[2] ; Yu,Xue ^[1] ; Na,Ye ^[1] ; Pei-Yong,Shi ^[3] ; Jia,Zhou ^[4]

作者单位： Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX 77555, United States. ^[1] Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, United States. ^[2] Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, United States; Sealy Center for Structural Biology and Molecular Biophysics, University of Texas Medical Branch, Galveston, TX 77555, United States. Electronic address: peshi@utmb.edu. ^[3] Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX 77555, United States; Sealy Center for Structural Biology and Molecular Biophysics, University of Texas Medical Branch, Galveston, TX 77555, United States. Electronic address: jizhou@utmb.edu. ^[4]

关键词 Antiviral agents Dengue virus NS4B inhibitors Spiropyrazolopyridone Structure-activity relationship (SAR)

医学主题词抗病毒药(Antiviral Agents);细胞系(Cell Line);细胞存活(Cell Survival);登革热病毒(Dengue Virus);药物设计(Drug Design);人类(Humans);膜蛋白质类(Membrane Proteins);吡啶酮类(Pyridones);螺环化合物(Spiro Compounds);构效关系(Structure-Activity Relationship);病毒非结构蛋白质类(Viral Nonstructural Proteins)

DOI 10.1016/j.bmcl.2020.127162

PMID 32247736

发布时间 2025-05-30

基金项目

R01 AI127744/AI/NIAID NIH HHS/United States R41 AI136126/AI/NIAID NIH HHS/United States U01CK000512/ACL/ACL HHS/United States U19 AI142759/AI/NIAID NIH HHS/United States U01 CK000512/CK/NCEZID CDC HHS/United States

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