作者:
Samuel W,Kazer [1]
;
Toby P,Aicher [2]
;
Daniel M,Muema [3]
;
Shaina L,Carroll [4]
;
Jose,Ordovas-Montanes [5]
;
Vincent N,Miao [6]
;
Ang A,Tu [7]
;
Carly G K,Ziegler [6]
;
Sarah K,Nyquist [8]
;
Emily B,Wong [9]
;
Nasreen,Ismail [10]
;
Mary,Dong [11]
;
Amber,Moodley [10]
;
Bonnie,Berger [12]
;
J Christopher,Love [13]
;
Krista L,Dong [11]
;
Alasdair,Leslie [14]
;
Zaza M,Ndhlovu [15]
;
Thumbi,Ndung'u [16]
;
Bruce D,Walker [17]
;
Alex K,Shalek [18]
作者单位:
Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.;Institute for Medical Engineering and Science (IMES), Massachusetts Institute of Technology, Cambridge, MA, USA.;Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.;Broad Institute of MIT and Harvard, Cambridge, MA, USA.
[1]
Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.;Institute for Medical Engineering and Science (IMES), Massachusetts Institute of Technology, Cambridge, MA, USA.;Broad Institute of MIT and Harvard, Cambridge, MA, USA.
[2]
African Health Research Institute, Durban, South Africa.;HIV Pathogenesis Programme, Nelson R. Mandela School of Medicine, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.
[3]
Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA.
[4]
Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.;Institute for Medical Engineering and Science (IMES), Massachusetts Institute of Technology, Cambridge, MA, USA.;Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.;Broad Institute of MIT and Harvard, Cambridge, MA, USA.;Division of Gastroenterology, Boston Children's Hospital, Boston, MA, USA.;Harvard Stem Cell Institute, Cambridge, MA, USA.
[5]
Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.;Institute for Medical Engineering and Science (IMES), Massachusetts Institute of Technology, Cambridge, MA, USA.;Broad Institute of MIT and Harvard, Cambridge, MA, USA.;Program in Health Sciences and Technology, Harvard Medical School & Massachusetts Institute of Technology, Boston, MA, USA.
[6]
Broad Institute of MIT and Harvard, Cambridge, MA, USA.;Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.;Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
[7]
Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.;Institute for Medical Engineering and Science (IMES), Massachusetts Institute of Technology, Cambridge, MA, USA.;Broad Institute of MIT and Harvard, Cambridge, MA, USA.;Program in Computational and Systems Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.;Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA.
[8]
African Health Research Institute, Durban, South Africa.;Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA.;Division of Infection and Immunity, University College London, London, UK.;Harvard Medical School, Boston, MA, USA.
[9]
HIV Pathogenesis Programme, Nelson R. Mandela School of Medicine, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.
[10]
Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
[11]
Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA.;Department of Mathematics, Massachusetts Institute of Technology, Cambridge, MA, USA.
[12]
Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.;Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.;Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
[13]
African Health Research Institute, Durban, South Africa.;Division of Infection and Immunity, University College London, London, UK.
[14]
Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.;African Health Research Institute, Durban, South Africa.;HIV Pathogenesis Programme, Nelson R. Mandela School of Medicine, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.;Howard Hughes Medical Institute, Chevy Chase, MD, USA.
[15]
Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.;African Health Research Institute, Durban, South Africa.;HIV Pathogenesis Programme, Nelson R. Mandela School of Medicine, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.;Division of Infection and Immunity, University College London, London, UK.;Max Planck Institute for Infection Biology, Berlin, Germany.
[16]
Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA. BWALKER@mgh.harvard.edu.;HIV Pathogenesis Programme, Nelson R. Mandela School of Medicine, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa. BWALKER@mgh.harvard.edu.;Howard Hughes Medical Institute, Chevy Chase, MD, USA. BWALKER@mgh.harvard.edu.
[17]
Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA. shalek@mit.edu.;Institute for Medical Engineering and Science (IMES), Massachusetts Institute of Technology, Cambridge, MA, USA. shalek@mit.edu.;Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA. shalek@mit.edu.;Broad Institute of MIT and Harvard, Cambridge, MA, USA. shalek@mit.edu.;Program in Health Sciences and Technology, Harvard Medical School & Massachusetts Institute of Technology, Boston, MA, USA. shalek@mit.edu.;Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA. shalek@mit.edu.;Program in Computational and Systems Biology, Massachusetts Institute of Technology, Cambridge, MA, USA. shalek@mit.edu.
[18]
主题词
急性病(Acute Disease);急相反应(Acute-Phase Reaction);青少年(Adolescent);成年人(Adult);细胞间通讯(Cell Communication);女(雌)性(Female);基因表达谱(Gene Expression Profiling);基因调控网络(Gene Regulatory Networks);HIV感染(HIV Infections);HIV-1(HIV-1);人类(Humans);免疫, 细胞(Immunity, Cellular);杀伤细胞, 天然(Killer Cells, Natural);白细胞, 单核(Leukocytes, Mononuclear);纵向研究(Longitudinal Studies);序列分析, RNA(Sequence Analysis, RNA);单细胞分析(Single-Cell Analysis);系统综合(Systems Integration);T淋巴细胞, 细胞毒性(T-Lymphocytes, Cytotoxic);病毒载量(Viral Load);青年人(Young Adult)
DOI
10.1038/s41591-020-0799-2
PMID
32251406
发布时间
2024-12-07
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Nature medicine
Nature medicine
511-518页
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