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Integrated single-cell analysis of multicellular immune dynamics during hyperacute HIV-1 infection.

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作者单位: Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.;Institute for Medical Engineering and Science (IMES), Massachusetts Institute of Technology, Cambridge, MA, USA.;Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.;Broad Institute of MIT and Harvard, Cambridge, MA, USA. [1] Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.;Institute for Medical Engineering and Science (IMES), Massachusetts Institute of Technology, Cambridge, MA, USA.;Broad Institute of MIT and Harvard, Cambridge, MA, USA. [2] African Health Research Institute, Durban, South Africa.;HIV Pathogenesis Programme, Nelson R. Mandela School of Medicine, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa. [3] Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA. [4] Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.;Institute for Medical Engineering and Science (IMES), Massachusetts Institute of Technology, Cambridge, MA, USA.;Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.;Broad Institute of MIT and Harvard, Cambridge, MA, USA.;Division of Gastroenterology, Boston Children's Hospital, Boston, MA, USA.;Harvard Stem Cell Institute, Cambridge, MA, USA. [5] Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.;Institute for Medical Engineering and Science (IMES), Massachusetts Institute of Technology, Cambridge, MA, USA.;Broad Institute of MIT and Harvard, Cambridge, MA, USA.;Program in Health Sciences and Technology, Harvard Medical School & Massachusetts Institute of Technology, Boston, MA, USA. [6] Broad Institute of MIT and Harvard, Cambridge, MA, USA.;Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.;Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. [7] Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.;Institute for Medical Engineering and Science (IMES), Massachusetts Institute of Technology, Cambridge, MA, USA.;Broad Institute of MIT and Harvard, Cambridge, MA, USA.;Program in Computational and Systems Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.;Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA. [8] African Health Research Institute, Durban, South Africa.;Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA.;Division of Infection and Immunity, University College London, London, UK.;Harvard Medical School, Boston, MA, USA. [9] HIV Pathogenesis Programme, Nelson R. Mandela School of Medicine, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa. [10] Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA. [11] Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA.;Department of Mathematics, Massachusetts Institute of Technology, Cambridge, MA, USA. [12] Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.;Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.;Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. [13] African Health Research Institute, Durban, South Africa.;Division of Infection and Immunity, University College London, London, UK. [14] Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.;African Health Research Institute, Durban, South Africa.;HIV Pathogenesis Programme, Nelson R. Mandela School of Medicine, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.;Howard Hughes Medical Institute, Chevy Chase, MD, USA. [15] Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.;African Health Research Institute, Durban, South Africa.;HIV Pathogenesis Programme, Nelson R. Mandela School of Medicine, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa.;Division of Infection and Immunity, University College London, London, UK.;Max Planck Institute for Infection Biology, Berlin, Germany. [16] Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA. BWALKER@mgh.harvard.edu.;HIV Pathogenesis Programme, Nelson R. Mandela School of Medicine, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa. BWALKER@mgh.harvard.edu.;Howard Hughes Medical Institute, Chevy Chase, MD, USA. BWALKER@mgh.harvard.edu. [17] Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA. shalek@mit.edu.;Institute for Medical Engineering and Science (IMES), Massachusetts Institute of Technology, Cambridge, MA, USA. shalek@mit.edu.;Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA. shalek@mit.edu.;Broad Institute of MIT and Harvard, Cambridge, MA, USA. shalek@mit.edu.;Program in Health Sciences and Technology, Harvard Medical School & Massachusetts Institute of Technology, Boston, MA, USA. shalek@mit.edu.;Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA. shalek@mit.edu.;Program in Computational and Systems Biology, Massachusetts Institute of Technology, Cambridge, MA, USA. shalek@mit.edu. [18]
DOI 10.1038/s41591-020-0799-2
PMID 32251406
发布时间 2024-12-07
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