DC591017, a phosphodiesterase-4 (PDE4) inhibitor with robust anti-inflammation through regulating PKA-CREB signaling.

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第一作者： Heng,Li

第一单位： Laboratory of Anti-inflammation and Immunopharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; School of Pharmacy, University of Chinese Academy of Sciences, Beijing 100049, China.

作者： Heng,Li ^[1] ; Jian,Li ^[2] ; Xianglei,Zhang ^[3] ; Chunlan,Feng ^[4] ; Chen,Fan ^[4] ; Xiaoqian,Yang ^[4] ; Rui,Zhang ^[5] ; Fenghua,Zhu ^[4] ; Yu,Zhou ^[4] ; Yechun,Xu ^[3] ; Hong,Liu ^[5] ; Wei,Tang ^[6]

作者单位： Laboratory of Anti-inflammation and Immunopharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; School of Pharmacy, University of Chinese Academy of Sciences, Beijing 100049, China. ^[1] State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. ^[2] School of Pharmacy, University of Chinese Academy of Sciences, Beijing 100049, China; CAS Key Laboratory of Receptor Research, Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. ^[3] Laboratory of Anti-inflammation and Immunopharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. ^[4] School of Pharmacy, University of Chinese Academy of Sciences, Beijing 100049, China; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. ^[5] Laboratory of Anti-inflammation and Immunopharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; School of Pharmacy, University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address: tangwei@simm.ac.cn. ^[6]

关键词 DC591017 Dendritic cells Inflammation Macrophages PDE4 Psoriasis