首页> American journal of physiology. Endocrinology and metabolism> The inducible β5i proteasome subunit contributes to proinsulin degradation in GRP94-deficient β-cells and is overexpressed in type 2 diabetes pancreatic islets.

The inducible β5i proteasome subunit contributes to proinsulin degradation in GRP94-deficient β-cells and is overexpressed in type 2 diabetes pancreatic islets.

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第一作者： Muhammad Saad,Khilji

第一单位： Laboratory of Immuno-endocrinology, Inflammation, Metabolism, and Oxidation Section, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.

作者： Muhammad Saad,Khilji ^[1] ; Sophie Emilie,Bresson ^[1] ; Danielle,Verstappen ^[2] ; Celina,Pihl ^[1] ; Phillip Alexander Keller,Andersen ^[1] ; Jette Bach,Agergaard ^[1] ; Tina,Dahlby ^[1] ; Tenna Holgersen,Bryde ^[1] ; Kristian,Klindt ^[1] ; Christian Kronborg,Nielsen ^[1] ; Anna,Walentinsson ^[3] ; Dusan,Zivkovic ^[4] ; Marie-Pierre,Bousquet ^[4] ; Björn,Tyrberg ^[5] ; Sarah J,Richardson ^[6] ; Noel G,Morgan ^[6] ; Thomas,Mandrup-Poulsen ^[1] ; Michal Tomasz,Marzec ^[1]

作者单位： Laboratory of Immuno-endocrinology, Inflammation, Metabolism, and Oxidation Section, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark. ^[1] Laboratory of Immuno-endocrinology, Inflammation, Metabolism, and Oxidation Section, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.;Radboud Universiteit, Nijmegen, The Netherlands. ^[2] Translational Science and Experimental Medicine, Early Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden. ^[3] Institut de Pharmacologie et de Biologie Structurale, Centre National de la Recherche Scientifique, Université de Toulouse, Toulouse, France. ^[4] Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. ^[5] Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, Exeter, United Kingdom. ^[6]

关键词 GRP94 proinsulin degradation proteasome restoration of proinsulin β5i