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Comprehensive routine diagnostic screening to identify predictive mutations, gene amplifications, and microsatellite instability in FFPE tumor material.

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第一作者： Elisabeth M P,Steeghs

第一单位： Department of Pathology, Radboud university medical center, PO Box 9101, 6500, HB, Nijmegen, the Netherlands.

作者： Elisabeth M P,Steeghs ^[1] ; Leonie I,Kroeze ^[1] ; Bastiaan B J,Tops ^[2] ; Leon C,van Kempen ^[3] ; Arja,Ter Elst ^[3] ; Annemiek W M,Kastner-van Raaij ^[1] ; Sandra J B,Hendriks-Cornelissen ^[1] ; Mandy J W,Hermsen ^[1] ; Erik A M,Jansen ^[4] ; Petra M,Nederlof ^[5] ; Ed,Schuuring ^[3] ; Marjolijn J L,Ligtenberg ^[6] ; Astrid,Eijkelenboom ^[7]

作者单位： Department of Pathology, Radboud university medical center, PO Box 9101, 6500, HB, Nijmegen, the Netherlands. ^[1] Department of Pathology, Radboud university medical center, PO Box 9101, 6500, HB, Nijmegen, the Netherlands.;Department of Pathology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands. ^[2] Department of Pathology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. ^[3] Department of Human Genetics, Radboud university medical center, Nijmegen, The Netherlands. ^[4] Department of Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands. ^[5] Department of Pathology, Radboud university medical center, PO Box 9101, 6500, HB, Nijmegen, the Netherlands.;Department of Human Genetics, Radboud university medical center, Nijmegen, The Netherlands. ^[6] Department of Pathology, Radboud university medical center, PO Box 9101, 6500, HB, Nijmegen, the Netherlands. Astrid.Eijkelenboom@radboudumc.nl. ^[7]

关键词 Colorectal carcinoma FFPE GIST Gene amplification Lung cancer Melanoma Microsatellite instability Mutation Next-generation sequencing Predictive analysis