Structure of Super-Potent Antibody CAP256-VRC26.25 in Complex with HIV-1 Envelope Reveals a Combined Mode of Trimer-Apex Recognition.

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第一作者： Jason,Gorman

第一单位： Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

作者： Jason,Gorman ^[1] ; Gwo-Yu,Chuang ^[1] ; Yen-Ting,Lai ^[1] ; Chen-Hsiang,Shen ^[1] ; Jeffrey C,Boyington ^[1] ; Aliaksandr,Druz ^[1] ; Hui,Geng ^[1] ; Mark K,Louder ^[1] ; Krisha,McKee ^[1] ; Reda,Rawi ^[1] ; Raffaello,Verardi ^[1] ; Yongping,Yang ^[1] ; Baoshan,Zhang ^[1] ; Nicole A,Doria-Rose ^[1] ; Bob,Lin ^[1] ; Penny L,Moore ^[2] ; Lynn,Morris ^[2] ; Lawrence,Shapiro ^[3] ; John R,Mascola ^[1] ; Peter D,Kwong ^[4]

作者单位： Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. ^[1] Center for HIV and STIs, National Institute for Communicable Diseases of the National Health Laboratory Service (NHLS), Johannesburg 2192, South Africa; Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2050, South Africa; Centre for the AIDS Programme of Research in South Africa (CAPRISA), University of KwaZulu-Natal, Congella 4013, South Africa. ^[2] Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA. ^[3] Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA. Electronic address: pdkwong@nih.gov. ^[4]

关键词 HIV-1 envelope trimer PCT64 PG9 PGDM1400 PGT145 V1V2 apex recognition broadly neutralizing antibody multidonor antibody class tyrosine sulfation