Meta-analysis of cardiomyopathy-associated variants in troponin genes identifies loci and intragenic hot spots that are associated with worse clinical outcomes.

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第一作者： Hanna J,Tadros

第一单位： Department of Pediatrics, Section of Cardiology, Baylor College of Medicine, Houston, TX, United States; Department of Pediatrics, University of Florida, Gainesville, FL, United States.

作者： Hanna J,Tadros ^[1] ; Chelsea S,Life ^[2] ; Gustavo,Garcia ^[2] ; Elisa,Pirozzi ^[3] ; Edward G,Jones ^[4] ; Susmita,Datta ^[5] ; Michelle S,Parvatiyar ^[6] ; P Bryant,Chase ^[7] ; Hugh D,Allen ^[8] ; Jeffrey J,Kim ^[8] ; Jose R,Pinto ^[2] ; Andrew P,Landstrom ^[9]

作者单位： Department of Pediatrics, Section of Cardiology, Baylor College of Medicine, Houston, TX, United States; Department of Pediatrics, University of Florida, Gainesville, FL, United States. ^[1] Department of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, United States. ^[2] Department of Pediatrics, Division of Cardiology, Duke University School of Medicine, Durham, NC, United States. ^[3] Department of Pediatrics, Baylor College of Medicine, Houston, TX, United States. ^[4] Department of Biostatistics, University of Florida, Gainesville, FL, United States. ^[5] Department of Nutrition, Food and Exercise Sciences, Florida State University, Tallahassee, FL, United States. ^[6] Department of Biological Science, Florida State University, Tallahassee, FL, United States. ^[7] Department of Pediatrics, Section of Cardiology, Baylor College of Medicine, Houston, TX, United States. ^[8] Department of Pediatrics, Section of Cardiology, Baylor College of Medicine, Houston, TX, United States; Department of Pediatrics, Division of Cardiology, Duke University School of Medicine, Durham, NC, United States. Electronic address: andrew.landstrom@duke.edu. ^[9]

关键词 Cardiomyopathy Signal-to-noise analysis TNNC1 TNNI3 TNNT2 Troponin Troponin C Troponin I Troponin T