Concentration-Dependent Activity of Hydromethylthionine on Clinical Decline and Brain Atrophy in a Randomized Controlled Trial in Behavioral Variant Frontotemporal Dementia.

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作者： Helen,Shiells ^[1] ; Bjoern O,Schelter ^[1] ; Peter,Bentham ^[2] ; Thomas C,Baddeley ^[1] ; Christopher M,Rubino ^[1] ; Harish,Ganesan ^[3] ; Jeffrey,Hammel ^[4] ; Vesna,Vuksanovic ^[4] ; Roger T,Staff ^[4] ; Alison D,Murray ^[5] ; Luc,Bracoud ^[6] ; Damon J,Wischik ^[5] ; Gernot,Riedel ^[7] ; Serge,Gauthier ^[1] ; Jianping,Jia ^[8] ; Hans J,Moebius ^[9] ; Jiri,Hardlund ^[10] ; Christopher M,Kipps ^[11] ; Karin,Kook ^[12] ; John M D,Storey ^[1] ; Charles R,Harrington ^[13] ; Claude M,Wischik ^[14]

作者单位： TauRx Therapeutics Ltd., Aberdeen, UK. ^[1] Institute for Complex Systems and Mathematical Biology, University of Aberdeen, Aberdeen, UK. ^[2] Department of Chemistry, University of Aberdeen, Aberdeen, UK. ^[3] Institute of Clinical Pharmacodynamics, Schenectady, NY, USA. ^[4] Aberdeen Biomedical Imaging Centre, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, UK. ^[5] Aberdeen Royal Infirmary, NHS Grampian, Aberdeen, UK. ^[6] Bioclinica, Lyon, France. ^[7] Department of Computer Science and Technology, University of Cambridge, Cambridge, UK. ^[8] School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Foresterhill, Aberdeen, UK. ^[9] McGill Centre for Studies in Aging, Alzheimer's Disease Research Unit, and Douglas Mental Health University Institute, Montreal, QC, Canada. ^[10] Beijing Institute for Brain Disorders Alzheimer's Disease Centre, Beijing, China. ^[11] Moebius-Consult, Baar, Switzerland. ^[12] University Hospital Southampton and University of Southampton, UK. ^[13] Salamandra LLC, Bethesda, MD, USA. ^[14]

关键词 Behavioral variant frontotemporal dementia TDP-43 clinical trials hydromethylthionine leucomethylthioninium tau protein