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首页> Theranostics> The WW domains dictate isoform-specific regulation of YAP1 stability and pancreatic cancer cell malignancy.

The WW domains dictate isoform-specific regulation of YAP1 stability and pancreatic cancer cell malignancy.

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作者： Qiang,Guo ^[1] ; Meiyu,Quan ^[1] ; Jinglai,Dong ^[2] ; Jing,Bai ^[1] ; Jie,Wang ^[1] ; Rui,Han ^[1] ; Wei,Wang ^[2] ; Yaxin,Cai ^[2] ; Yu-Qing,Lv ^[2] ; Qianjie,Chen ^[1] ; Huijing,Xu ^[1] ; Han-Deng,Lyu ^[1] ; Liancheng,Deng ^[2] ; Depu,Zhou ^[1] ; Xueyuan,Xiao ^[3] ; Stijn,De Langhe ^[4] ; Daniel D,Billadeau ^[5] ; Zhenkun,Lou ^[5] ; Jin-San,Zhang ^[1]

作者单位： School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China. ^[1] Center for Precision Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China. ^[2] Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, Beijing Normal University, Beijing 100875, China. ^[3] Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, 35294-2182 AL, USA. ^[4] Division of Oncology Research, and Schulze Center for Novel Therapeutics, Mayo Clinic, Rochester, MN 55905, USA. ^[5] Institute of Life Sciences, Wenzhou University, Wenzhou, Zhejiang 325035, China. ^[6]

关键词 LATS1 WW domain YAP1 isoform pancreatic cancer protein stability

主题词衔接蛋白质类, 信号转导(Adaptor Proteins, Signal Transducing);腺癌(Adenocarcinoma);动物(Animals);细胞系, 肿瘤(Cell Line, Tumor);细胞转化, 肿瘤(Cell Transformation, Neoplastic);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);HEK293细胞(HEK293 Cells);人类(Humans);男(雄)性(Male);小鼠(Mice);小鼠, 近交BALB C(Mice, Inbred BALB C);小鼠, 裸(Mice, Nude);肿瘤侵润(Neoplasm Invasiveness);胰腺肿瘤(Pancreatic Neoplasms);蛋白质亚型(Protein Isoforms);RNA, 信使(RNA, Messenger);转录因子(Transcription Factors)

DOI 10.7150/thno.42795

PMID 32292505

发布时间 2023-12-13

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Theranostics

Theranostics

2020年10卷10期

4422-4436页

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