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Transcription Dynamics Regulate Poly(A) Tails and Expression of the RNA Degradation Machinery to Balance mRNA Levels.

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第一作者： Boris,Slobodin

第一单位： Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot 76100, Israel. Electronic address: boris.slobodin@gmail.com.

作者： Boris,Slobodin ^[1] ; Anat,Bahat ^[2] ; Urmila,Sehrawat ^[2] ; Shirly,Becker-Herman ^[3] ; Binyamin,Zuckerman ^[4] ; Amanda N,Weiss ^[2] ; Ruiqi,Han ^[5] ; Ran,Elkon ^[6] ; Reuven,Agami ^[5] ; Igor,Ulitsky ^[4] ; Idit,Shachar ^[3] ; Rivka,Dikstein ^[7]

作者单位： Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot 76100, Israel. Electronic address: boris.slobodin@gmail.com. ^[1] Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot 76100, Israel. ^[2] Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel. ^[3] Department of Biological Regulation, The Weizmann Institute of Science, Rehovot 76100, Israel. ^[4] Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands. ^[5] Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel. ^[6] Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot 76100, Israel. Electronic address: rivka.dikstein@weizmann.ac.il. ^[7]

关键词 CCR4-Not complex IRES RNA polymerase II gene expression buffering m(6)A m6A methyltransferase complex mRNA buffering mRNA degradation poly(A) tails transcription