Diversity Oriented Clicking (DOC): Divergent Synthesis of SuFExable Pharmacophores from 2-Substituted-Alkynyl-1-Sulfonyl Fluoride (SASF) Hubs.

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作者： Christopher J,Smedley ^[1] ; Gencheng,Li ^[2] ; Andrew S,Barrow ^[1] ; Timothy L,Gialelis ^[1] ; Marie-Claire,Giel ^[1] ; Alessandra,Ottonello ^[1] ; Yunfei,Cheng ^[2] ; Seiya,Kitamura ^[3] ; Dennis W,Wolan ^[3] ; K Barry,Sharpless ^[2] ; John E,Moses ^[1]

作者单位： La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, 3086, Australia. ^[1] Department of Chemistry, The Scripps Research Institute, La Jolla, CA, 92037, USA. ^[2] Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, 92037, USA. ^[3] Cancer Center, Cold Spring Harbor Laboratory, 1 Bungtown Rd, Cold Spring Harbor, NY, 11724, USA. ^[4]

关键词 SuFEx click chemistry cycloadditions diversity oriented clicking heterocycles sulfonyl fluorides

主题词链接化学(Click Chemistry);分子结构(Molecular Structure);亚磺酸类(Sulfinic Acids)

DOI 10.1002/anie.202003219

PMID 32301265

发布时间 2023-05-03

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