Patch-Seq Links Single-Cell Transcriptomes to Human Islet Dysfunction in Diabetes.

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作者： Joan,Camunas-Soler ^[1] ; Xiao-Qing,Dai ^[2] ; Yan,Hang ^[3] ; Austin,Bautista ^[2] ; James,Lyon ^[4] ; Kunimasa,Suzuki ^[4] ; Seung K,Kim ^[5] ; Stephen R,Quake ^[6] ; Patrick E,MacDonald ^[7]

作者单位： Department of Bioengineering, Stanford University, Stanford, CA 94305, USA; Chan Zuckerberg Biohub, San Francisco, CA 94518, USA. ^[1] Department of Pharmacology, University of Alberta, Edmonton, AB T6G 2E1, Canada; Alberta Diabetes Institute, University of Alberta, Edmonton, AB T6G 2E1, Canada. ^[2] Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA. ^[3] Alberta Diabetes Institute, University of Alberta, Edmonton, AB T6G 2E1, Canada. ^[4] Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA; Stanford Diabetes Research Center, Stanford University, Stanford, CA 94305, USA. Electronic address: seungkim@stanford.edu. ^[5] Department of Bioengineering, Stanford University, Stanford, CA 94305, USA; Chan Zuckerberg Biohub, San Francisco, CA 94518, USA; Stanford Diabetes Research Center, Stanford University, Stanford, CA 94305, USA; Department of Applied Physics, Stanford University, Stanford, CA 94305, USA. Electronic address: steve@quake-lab.org. ^[6] Department of Pharmacology, University of Alberta, Edmonton, AB T6G 2E1, Canada; Alberta Diabetes Institute, University of Alberta, Edmonton, AB T6G 2E1, Canada. Electronic address: pmacdonald@ualberta.ca. ^[7]

关键词 T1D T2D alpha cell beta cell cryopreservation diabetes islet pancreas patch-seq single-cell RNA-seq

主题词糖尿病, 1型(Diabetes Mellitus, Type 1);糖尿病, 2型(Diabetes Mellitus, Type 2);人类(Humans);胰岛(Islets of Langerhans);序列分析, RNA(Sequence Analysis, RNA);单细胞分析(Single-Cell Analysis)

DOI 10.1016/j.cmet.2020.04.005

PMID 32302527

发布时间 2021-11-09

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