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Cutaneous barrier leakage and gut inflammation drive skin disease in Omenn syndrome.

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作者单位: Milan Unit, Institute for Genetic and Biomedical Research (IRGB) National Research Council (CNR), Milan, Italy; Humanitas Clinical and Research Center IRCCS, Rozzano, Milan, Italy. [1] Humanitas Clinical and Research Center IRCCS, Rozzano, Milan, Italy. [2] Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), Bethesda, Md. [3] Department of Food, Environmental, and Nutritional Sciences, University of Milan Milan, Italy. [4] Humanitas Clinical and Research Center IRCCS, Rozzano, Milan, Italy; Humanitas University, Rozzano, Milan, Italy. [5] Centro Ricerca Tettamanti, Clinica Pediatrica, Università Milano-Bicocca, Monza, Italy. [6] Department of Pediatrics, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait; Allergy and Clinical Immunology Unit, Pediatric Department, Al-Sabah Hospital, Kuwait City, Kuwait. [7] Facultad de Medicina, Universidad Autónoma del Estado de Morelos, Cuernavaca, Mexico. [8] Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany. [9] Great North Children's Hospital, Clinical Resource Building, Newcastle upon Tyne, United Kingdom; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom. [10] National Human Genome Research Institute, NIH, Bethesda, Md. [11] Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy; Cytogenetic and Medical Genetics Unit, "A. Nocivelli" Institute for Molecular Medicine, Spedali Civili Hospital, Brescia, Italy. [12] Department of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut, Lebanon. [13] Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, Mass. [14] Department of Pediatrics, Universitair Ziekenhuis Leuven, University Hospitals Leuven, Leuven, Belgium; Laboratory for Inborn Errors of Immunity, Department of Immunology, Microbiology and Transplantation, Katholieke Universiteit Leuven, Leuven, Belgium. [15] Lab for Translational Cell and Tissue Research, Department of Imaging and Pathology, Katholieke Universiteit Leuven, Leuven, Belgium. [16] Imagine Institute, Paris Descartes-Sorbonne Paris Cité University, Paris, France; Pediatric Immuno-Hematology Unit, Necker Children Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France. [17] Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Ulm, Germany. [18] Department of Pediatrics, Children's Hospital Bambino Gesù, Rome, Italy. [19] Neutrophil Monitoring Laboratory, Leidos Biomedical Research, Inc, Frederick National Laboratory for Cancer Research, Frederick, Md. [20] Fungal Pathogenesis Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Md. [21] Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Md. [22] Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), Bethesda, Md. Electronic address: luigi.notarangelo2@nih.gov. [23] Milan Unit, Institute for Genetic and Biomedical Research (IRGB) National Research Council (CNR), Milan, Italy; Telethon Institute for Gene Therapy, Division of Regenerative Medicine, Stem Cells, and Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy. Electronic address: villa.anna@hsr.it. [24] Milan Unit, Institute for Genetic and Biomedical Research (IRGB) National Research Council (CNR), Milan, Italy; Humanitas Clinical and Research Center IRCCS, Rozzano, Milan, Italy. Electronic address: barbara.cassani@humanitasresearch.it. [25]
DOI 10.1016/j.jaci.2020.04.005
PMID 32311393
发布时间 2021-08-08
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