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Developing spray-freeze-dried particles containing a hyaluronic acid-coated liposome-protamine-DNA complex for pulmonary inhalation.

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第一作者： Kaori,Fukushige

第一单位： Department of Anatomy, School of Medicine, Aichi Medical University, 1-1 Yazakokarimata, Nagakute, Aichi 480-1195, Japan; Drug Delivery and Nano Pharmaceutics, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, Aichi 467-8603, Japan. Electronic address: kaori.fukushige@gmail.com.

作者： Kaori,Fukushige ^[1] ; Tatsuaki,Tagami ^[2] ; Munekazu,Naito ^[3] ; Eiichi,Goto ^[2] ; Shuichi,Hirai ^[3] ; Naoyuki,Hatayama ^[3] ; Hiroki,Yokota ^[3] ; Takao,Yasui ^[4] ; Yoshinobu,Baba ^[4] ; Tetsuya,Ozeki ^[2]

作者单位： Department of Anatomy, School of Medicine, Aichi Medical University, 1-1 Yazakokarimata, Nagakute, Aichi 480-1195, Japan; Drug Delivery and Nano Pharmaceutics, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, Aichi 467-8603, Japan. Electronic address: kaori.fukushige@gmail.com. ^[1] Drug Delivery and Nano Pharmaceutics, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, Aichi 467-8603, Japan. ^[2] Department of Anatomy, School of Medicine, Aichi Medical University, 1-1 Yazakokarimata, Nagakute, Aichi 480-1195, Japan. ^[3] Department of Biomolecular Engineering, Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, Aichi 464-8603, Japan. ^[4]

关键词 Hyaluronic acid Lipid nanoparticle Liposome–protamine–DNA complex (LPD)Nanoparticles-in-microparticles Small interfering RNA (siRNA)Spray-freeze-drying