Gut microbiota generation of protein-bound uremic toxins and related metabolites is not altered at different stages of chronic kidney disease.

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第一作者： Tessa,Gryp

第一单位： Department of Internal Medicine and Pediatrics, Nephrology Section, Ghent University Hospital, Ghent, Belgium; Department of Diagnostic Sciences, Laboratory Bacteriology Research, Ghent University, Ghent, Belgium; Department of Microbiology, Immunology and Transplantation, Molecular Microbiology-Microbiome Research Lab, KU Leuven, Leuven, Belgium. Electronic address: tessa.gryp@ugent.be.

作者： Tessa,Gryp ^[1] ; Kim,De Paepe ^[2] ; Raymond,Vanholder ^[3] ; Frederiek-Maarten,Kerckhof ^[2] ; Wim,Van Biesen ^[3] ; Tom,Van de Wiele ^[2] ; Francis,Verbeke ^[3] ; Marijn,Speeckaert ^[3] ; Marie,Joossens ^[4] ; Marie Madeleine,Couttenye ^[5] ; Mario,Vaneechoutte ^[6] ; Griet,Glorieux ^[3]

作者单位： Department of Internal Medicine and Pediatrics, Nephrology Section, Ghent University Hospital, Ghent, Belgium; Department of Diagnostic Sciences, Laboratory Bacteriology Research, Ghent University, Ghent, Belgium; Department of Microbiology, Immunology and Transplantation, Molecular Microbiology-Microbiome Research Lab, KU Leuven, Leuven, Belgium. Electronic address: tessa.gryp@ugent.be. ^[1] Department of Biotechnology, Center for Microbial Ecology and Technology, Ghent University, Ghent, Belgium. ^[2] Department of Internal Medicine and Pediatrics, Nephrology Section, Ghent University Hospital, Ghent, Belgium. ^[3] Department of Microbiology, Immunology and Transplantation, Molecular Microbiology-Microbiome Research Lab, KU Leuven, Leuven, Belgium. ^[4] Department of Nephrology, Antwerp University Hospital, Edegem, Belgium. ^[5] Department of Diagnostic Sciences, Laboratory Bacteriology Research, Ghent University, Ghent, Belgium. ^[6]

关键词 bacterial metabolization chronic kidney disease feces plasma protein-bound uremic toxins urine

主题词粪便(Feces);人类(Humans);靛甙(Indican);肾功能不全, 慢性(Renal Insufficiency, Chronic);毒素类, 生物学(Toxins, Biological);尿毒症(Uremia)

DOI 10.1016/j.kint.2020.01.028

PMID 32317112

发布时间 2021-06-21

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