首页> The Journal of biological chemistry> Small molecule AX-024 reduces T cell proliferation independently of CD3ϵ/Nck1 interaction, which is governed by a domain swap in the Nck1-SH3.1 domain.

Small molecule AX-024 reduces T cell proliferation independently of CD3ϵ/Nck1 interaction, which is governed by a domain swap in the Nck1-SH3.1 domain.

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第一作者： Kirsten,Richter

第一单位： I2O Disease Translational Area, pRED Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.

作者： Kirsten,Richter ^[1] ; Arne C,Rufer ^[2] ; Magali,Muller ^[1] ; Dominique,Burger ^[2] ; Fabio,Casagrande ^[2] ; Tabea,Grossenbacher ^[2] ; Sylwia,Huber ^[2] ; Melanie N,Hug ^[2] ; Philipp,Koldewey ^[2] ; Andrea,D'Osualdo ^[1] ; Daniel,Schlatter ^[2] ; Theodor,Stoll ^[2] ; Markus G,Rudolph ^[3]

作者单位： I2O Disease Translational Area, pRED Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland. ^[1] Therapeutic Modalities, Lead Discovery and Medicinal Chemistry, pRED Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland. ^[2] Therapeutic Modalities, Lead Discovery and Medicinal Chemistry, pRED Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland markus.rudolph@roche.com. ^[3]

关键词 T-cell receptor (TCR)adaptor protein analytical ultracentrifugation cell proliferation crystal structure nuclear magnetic resonance (NMR)protein drug interaction protein structure structure-function surface plasmon resonance (SPR)