Mst1 knockdown alleviates cardiac lipotoxicity and inhibits the development of diabetic cardiomyopathy in db/db mice.

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第一作者： Zhenyu,Xiong

第一单位： Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an, China; Department of Cardiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.

作者： Zhenyu,Xiong ^[1] ; Yueyang,Li ^[2] ; Zhengqing,Zhao ^[3] ; Yan,Zhang ^[2] ; Wanrong,Man ^[2] ; Jie,Lin ^[2] ; Yuan,Dong ^[2] ; Liyuan,Liu ^[2] ; Bo,Wang ^[2] ; Huan,Wang ^[2] ; Baolin,Guo ^[2] ; Congye,Li ^[2] ; Fei,Li ^[4] ; Haichang,Wang ^[5] ; Dongdong,Sun ^[6]

作者单位： Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an, China; Department of Cardiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, China. ^[1] Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an, China. ^[2] Department of Neurology, Changzheng Hospital, Second Military Medical University, Shanghai, China. ^[3] Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an, China. Electronic address: lifei01@fmmu.edu.cn. ^[4] Heart Hospital, Xi'an International Medical Center, Xi'an, China. Electronic address: wanghc@fmmu.edu.cn. ^[5] Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an, China. Electronic address: wintersun3@gmail.com. ^[6]

关键词 Diabetic cardiomyopathy Lipotoxicity Mammalian sterile 20-like kinase 1, Mst1 Type 2 diabetes mellitus

主题词动物(Animals);动物, 新生(Animals, Newborn);细胞凋亡(Apoptosis);糖尿病, 实验性(Diabetes Mellitus, Experimental);糖尿病, 2型(Diabetes Mellitus, Type 2);糖尿病心肌病(Diabetic Cardiomyopathies);脂肪酸类(Fatty Acids);基因表达调控(Gene Expression Regulation);肝细胞生长因子(Hepatocyte Growth Factor);人类(Humans);JNK丝裂原活化蛋白激酶类(JNK Mitogen-Activated Protein Kinases);MAP激酶激酶激酶1(MAP Kinase Kinase Kinase 1);男(雄)性(Male);膜电位, 线粒体(Membrane Potential, Mitochondrial);小鼠(Mice);小鼠, 转基因(Mice, Transgenic);线粒体(Mitochondria);肌细胞, 心脏(Myocytes, Cardiac);氧化还原(Oxidation-Reduction);启动区, 遗传(Promoter Regions, Genetic);原癌基因蛋白质类(Proto-Oncogene Proteins);RNA, 小分子干扰(RNA, Small Interfering);大鼠(Rats);信号传导(Signal Transduction)

DOI 10.1016/j.bbadis.2020.165806

PMID 32320827

发布时间 2021-12-04

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Biochimica et biophysica acta. Molecular basis of disease

2020年1866卷8期

165806页

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Mst1 knockdown alleviates cardiac lipotoxicity and inhibits the development of diabetic cardiomyopathy in db/db mice.

Biochimica et biophysica acta. Molecular basis of disease

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Biochimica et biophysica acta. Molecular basis of disease

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Mst1 knockdown alleviates cardiac lipotoxicity and inhibits the development of diabetic cardiomyopathy in db/db mice.

Biochimica et biophysica acta. Molecular basis of disease

相似文献

Biochimica et biophysica acta. Molecular basis of disease

相关期刊

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