Excipient-free pulmonary insulin dry powder: Pharmacokinetic and pharmacodynamics profiles in rats.

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第一作者： Eride,Quarta

第一单位： Food and Drug Department, University of Parma, Parco Area delle Scienze 27/A, 43124 Parma, Italy; Paolo Colombo and Eride Quarta. f: PlumeStars Srl, Strada Inzani 1, 43125 Parma, Italy.

作者： Eride,Quarta ^[1] ; Veronica,Chierici ^[2] ; Lisa,Flammini ^[3] ; Massimiliano,Tognolini ^[3] ; Elisabetta,Barocelli ^[3] ; Anna Maria,Cantoni ^[4] ; Gabriela,Dujovny ^[5] ; Susana,Ecenarro Probst ^[5] ; Fabio,Sonvico ^[3] ; Gaia,Colombo ^[6] ; Alessandra,Rossi ^[3] ; Ruggero,Bettini ^[3] ; Paolo,Colombo ^[1] ; Francesca,Buttini ^[7]

作者单位： Food and Drug Department, University of Parma, Parco Area delle Scienze 27/A, 43124 Parma, Italy; Paolo Colombo and Eride Quarta. f: PlumeStars Srl, Strada Inzani 1, 43125 Parma, Italy. ^[1] Interdepartmental Center for Innovation in Health Products, Biopharmanet_TEC, University of Parma, Parco Area delle Scienze 27/A, 43124 Parma, Italy. ^[2] Food and Drug Department, University of Parma, Parco Area delle Scienze 27/A, 43124 Parma, Italy. ^[3] Department of Veterinary Health Sciences, University of Parma, Strada del Taglio 8, 43126 Parma, Italy. ^[4] Qualicaps, Avenida Monte Valdelatas 4, 28108 Alcobendas, Madrid, Spain. ^[5] Department of Life Sciences and Biotechnology, Via Fossato di Mortara 17/19, 44121 Ferrara, Italy. ^[6] Food and Drug Department, University of Parma, Parco Area delle Scienze 27/A, 43124 Parma, Italy. Electronic address: francesca.buttini@unipr.it. ^[7]

关键词 Dry powder inhaler Excipient-free DPI Insulin Pharmacodynamics Pharmacokinetics Safety Stability