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Hypergastrinemia Expands Gastric ECL Cells Through CCK2R<sup>+</sup> Progenitor Cells via ERK Activation.

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第一作者： Weiwei,Sheng

第一单位： Division of Digestive and Liver Diseases, Department of Medicine; Department of Gastrointestinal Surgery, the First Hospital, China Medical University, Shenyang, China.

作者： Weiwei,Sheng ^[1] ; Ermanno,Malagola ^[2] ; Henrik,Nienhüser ^[2] ; Zhengyu,Zhang ^[2] ; Woosook,Kim ^[2] ; Leah,Zamechek ^[2] ; Antonia,Sepulveda ^[3] ; Masahiro,Hata ^[4] ; Yoku,Hayakawa ^[4] ; Chun-Mei,Zhao ^[5] ; Duan,Chen ^[5] ; Timothy C,Wang ^[6]

作者单位： Division of Digestive and Liver Diseases, Department of Medicine; Department of Gastrointestinal Surgery, the First Hospital, China Medical University, Shenyang, China. ^[1] Division of Digestive and Liver Diseases, Department of Medicine. ^[2] Department of Pathology, Columbia University, College of Physicians and Surgeons, New York, New York. ^[3] Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. ^[4] Department of Clinical and Molecular Medicine (Institutt for klinisk og molekylær medisin), Norwegian University of Science and Technology (Norges teknisk-naturvitenskaplige universitet), Trondheim, Norway. ^[5] Division of Digestive and Liver Diseases, Department of Medicine. Electronic address: tcw21@columbia.edu. ^[6]

关键词 CCK2R or Gastrin Receptor Cholecystokin-2 Receptor (CCK2R)Chromogranin A (CgA)Enterochromaffin-Like (ECL) Cells Gastrin Histidine Decarboxylase (Hdc)Progenitor Cell Proton Pump Inhibitors (PPI)Stem Cell Niche