FTIR spectroscopy as an analytical tool to compare glycosylation in therapeutic monoclonal antibodies.

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作者： Allison,Derenne ^[1] ; Kheiro-Mouna,Derfoufi ^[1] ; Ben,Cowper ^[2] ; Cédric,Delporte ^[3] ; Erik,Goormaghtigh ^[4]

作者单位： Center for Structural Biology and Bioinformatics, Laboratory for the Structure and Function of Biological Membranes, Campus Plaine CP206/02, Université Libre de Bruxelles, Bld Du Triomphe 2, CP206/2, B1050, Brussels, Belgium. ^[1] National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar, Hertfordshire, EN6 3QG, United Kingdom. ^[2] RD3 - Pharmacognosy, Bioanalysis & Drug Discovery Unit & Analytical Platform of the Faculty of Pharmacy, Campus Plaine, CP2025/5, Université Libre de Bruxelles, Bld Du Triomphe 2, CP205/5, B1050, Brussels, Belgium. ^[3] Center for Structural Biology and Bioinformatics, Laboratory for the Structure and Function of Biological Membranes, Campus Plaine CP206/02, Université Libre de Bruxelles, Bld Du Triomphe 2, CP206/2, B1050, Brussels, Belgium. Electronic address: egoor@ulb.ac.be. ^[4]

关键词 Biosimilar FTIR spectroscopy Glycoproteins Glycosylation Infrared Monoclonal antibodies

主题词抗体, 单克隆(Antibodies, Monoclonal);糖蛋白类(Glycoproteins);糖基化(Glycosylation);人类(Humans);多糖类(Polysaccharides);蛋白质加工, 转译后(Protein Processing, Post-Translational);谱学, 傅里叶变换红外(Spectroscopy, Fourier Transform Infrared)

DOI 10.1016/j.aca.2020.03.038

PMID 32334683

发布时间 2020-12-29

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准确一般字义偏差语意偏离译文作用小提交