Fluidity and elasticity form a concise set of viscoelastic biomarkers for breast cancer diagnosis based on Kelvin-Voigt fractional derivative modeling.

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作者： Hongmei,Zhang ^[1] ; Ying,Guo ^[2] ; Yan,Zhou ^[1] ; Hongrui,Zhu ^[1] ; Pengying,Wu ^[1] ; Kai,Wang ^[3] ; Litao,Ruan ^[4] ; Mingxi,Wan ^[5] ; Michael F,Insana ^[6]

作者单位： The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an JiaoTong University, Xi'an, 710049, PR China. ^[1] Department of Pathology, School of Medicine, Northwest University, Xi'an, 710069, PR China. ^[2] Department of Pathology, Xi'an JiaoTong University Medical College First Affiliated Hospital, Xi'an, 710004, PR China. ^[3] Department of Medical Ultrasonics, Xi'an JiaoTong University Medical College First Affiliated Hospital, Xi'an, 710004, PR China. ^[4] The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an JiaoTong University, Xi'an, 710049, PR China. mxwan@mail.xjtu.edu.cn. ^[5] Department of Bioengineering, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA. mfi@illinois.edu. ^[6]

关键词 Cellular mechano-biology Gaussian mixture (GM) model Histopathology correlation Indentation-type atomic force microscopy (IT-AFM)Viscoelastic biomarker