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Dimethyl sulfoxide: a central player since the dawn of cryobiology, is efficacy balanced by toxicity?

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第一作者： Maooz,Awan

第一单位： Institute for Liver & Digestive Health, UCL Division of Medicine, Royal Free Hospital, UCL, London, NW3 2PF, UK.

作者： Maooz,Awan ^[1] ; Iryna,Buriak ^[2] ; Roland,Fleck ^[3] ; Barry,Fuller ^[4] ; Anatoliy,Goltsev ^[2] ; Julie,Kerby ^[5] ; Mark,Lowdell ^[6] ; Pavel,Mericka ^[7] ; Alexander,Petrenko ^[2] ; Yuri,Petrenko ^[8] ; Olena,Rogulska ^[2] ; Alexandra,Stolzing ^[9] ; Glyn N,Stacey ^[10]

作者单位： Institute for Liver & Digestive Health, UCL Division of Medicine, Royal Free Hospital, UCL, London, NW3 2PF, UK. ^[1] Institute for Problems of Cryobiology & Cryomedicine, National Academy of Sciences of Ukraine, Pereyaslavska 23, 61016, Kharkiv. ^[2] Centre for Ultrastructural Imaging, Kings College London, London, SE1 1UL, UK. ^[3] Department of Surgical Biotechnology, UCL Division of Surgery, Royal Free Hospital, UCL, London, NW3 2QG, UK. ^[4] Cell & Gene Therapy Catapult, 12th Floor Tower Wing, Guy's Hospital, Great Maze Pond, London, SE1 9RT, UK. ^[5] Centre for Cell, Gene & Tissue Therapy, Royal Free London NHS FT & UCL, London, NW3 2PF, UK. ^[6] Tissue Bank, University Hospital Hradec Kralové, Czech Republic. ^[7] Department of Biomaterials & Biophysical Methods, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic. ^[8] University of Loughborough, Centre for Biological Engineering, Loughborough University, Holywell Park, Loughborough, UK. ^[9] International Stem Cell Banking Initiative, 2 High Street, Barley, Hertfordshire, SG8 8HZ.;Beijing Stem Cell Bank, Institute of Zoology, Chinese Academy of Sciences, 25-2 Beishuan West, Haidan District, 100190 Beijing, China.;Institute of Stem Cells & Regeneration, Chinese Academy of Sciences, Beijing 100101, China. ^[10]

关键词 DMSO toxicity cell therapy cell therapy safety cryobiology cryopreservation cryoprotectant toxicity cryoprotectants dimethyl sulfoxide

医学主题词动物(Animals);细胞存活(Cell Survival);低温保存(Cryopreservation);低温防护剂(Cryoprotective Agents);二甲亚砜(Dimethyl Sulfoxide);人类(Humans);组织工程(Tissue Engineering)

DOI 10.2217/rme-2019-0145

PMID 32342730

发布时间 2021-06-07

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