Aberrant glycosaminoglycan biosynthesis by tumor suppressor EXTL2 deficiency promotes liver inflammation and tumorigenesis through Toll-like 4 receptor signaling.
作者:
主题词
动物(Animals);癌, 肝细胞(Carcinoma, Hepatocellular);细胞系(Cell Line);细胞转化, 肿瘤(Cell Transformation, Neoplastic);葡糖氨基聚糖类(Glycosaminoglycans);肝炎(Hepatitis);炎症(Inflammation);肝(Liver);肝肿瘤(Liver Neoplasms);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 基因敲除(Mice, Knockout);N-乙酰氨基葡糖转移酶类(N-Acetylglucosaminyltransferases);NF-κB(NF-kappa B);蛋白聚糖类(Proteoglycans);信号传导(Signal Transduction);Toll样受体4(Toll-Like Receptor 4)
DOI
10.1096/fj.201902076R
PMID
32347583
发布时间
2021-01-15
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FASEB journal
8385-8401页
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