A Human Antibody Neutralizes Different Flaviviruses by Using Different Mechanisms.

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第一作者： Shuijun,Zhang

第一单位： Program in Emerging Infectious Diseases, Duke-National University of Singapore Medical School, Singapore 169857, Singapore; Centre for BioImaging Sciences, National University of Singapore, Singapore 117557, Singapore.

作者： Shuijun,Zhang ^[1] ; Thomas,Loy ^[2] ; Thiam-Seng,Ng ^[1] ; Xin-Ni,Lim ^[1] ; Shyn-Yun Valerie,Chew ^[1] ; Ter Yong,Tan ^[1] ; Meihui,Xu ^[3] ; Victor A,Kostyuchenko ^[1] ; Farhana,Tukijan ^[3] ; Jian,Shi ^[4] ; Katja,Fink ^[5] ; Shee-Mei,Lok ^[6]

作者单位： Program in Emerging Infectious Diseases, Duke-National University of Singapore Medical School, Singapore 169857, Singapore; Centre for BioImaging Sciences, National University of Singapore, Singapore 117557, Singapore. ^[1] Singapore Immunology Network, Agency for Science, Technology and Research, Singapore 138632, Singapore; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore. ^[2] Singapore Immunology Network, Agency for Science, Technology and Research, Singapore 138632, Singapore. ^[3] Centre for BioImaging Sciences, National University of Singapore, Singapore 117557, Singapore; CryoEM unit, Department of Biological Sciences, National University of Singapore, Singapore 117557, Singapore. ^[4] Singapore Immunology Network, Agency for Science, Technology and Research, Singapore 138632, Singapore; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore. Electronic address: kfink@vir.bio. ^[5] Program in Emerging Infectious Diseases, Duke-National University of Singapore Medical School, Singapore 169857, Singapore; Centre for BioImaging Sciences, National University of Singapore, Singapore 117557, Singapore. Electronic address: sheemei.lok@duke-nus.edu.sg. ^[6]

关键词 cryoEM structure dengue virus human antibody membrane fusion virus aggregation virus neutralization zika virus

主题词黄病毒属(Flavivirus);人类(Humans);中和试验(Neutralization Tests)

DOI 10.1016/j.celrep.2020.107584

PMID 32348755

发布时间 2021-05-13

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