Mechanism of Virus Attenuation by Codon Pair Deoptimization.

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第一作者： Nicole,Groenke

第一单位： Institut für Virologie, Freie Universität Berlin, Robert-von-Ostertag-Str. 7-13, 14163 Berlin, Germany.

作者： Nicole,Groenke ^[1] ; Jakob,Trimpert ^[1] ; Sophie,Merz ^[2] ; Andelé M,Conradie ^[1] ; Emanuel,Wyler ^[3] ; Hongwei,Zhang ^[4] ; Orsalia-Georgia,Hazapis ^[3] ; Sebastian,Rausch ^[4] ; Markus,Landthaler ^[5] ; Nikolaus,Osterrieder ^[6] ; Dusan,Kunec ^[7]

作者单位： Institut für Virologie, Freie Universität Berlin, Robert-von-Ostertag-Str. 7-13, 14163 Berlin, Germany. ^[1] Institut für Veterinärpathologie, Freie Universität Berlin, Robert-von-Ostertag-Str. 15, 14163 Berlin, Germany. ^[2] Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Hannoversche Str. 28, 10115 Berlin, Germany. ^[3] Institut für Immunologie, Freie Universität Berlin, Robert-von-Ostertag-Str. 7-13, 14163 Berlin, Germany. ^[4] Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Hannoversche Str. 28, 10115 Berlin, Germany; IRI Life Sciences, Institute of Biology, Humboldt-Universität zu Berlin, Philippstraße 13, 10115 Berlin, Germany. ^[5] Institut für Virologie, Freie Universität Berlin, Robert-von-Ostertag-Str. 7-13, 14163 Berlin, Germany. Electronic address: no.34@fu-berlin.de. ^[6] Institut für Virologie, Freie Universität Berlin, Robert-von-Ostertag-Str. 7-13, 14163 Berlin, Germany. Electronic address: dusan.kunec@fu-berlin.de. ^[7]

关键词 attenuation codon bias codon pair bias codon pair deoptimization dinucleotide frequencies influenza A virus mRNA stability recoding synthetic attenuated virus engineering

主题词动物(Animals);密码子(Codon);DNA病毒(DNA Viruses);基因组, 病毒(Genome, Viral);人类(Humans);小鼠(Mice);病毒蛋白质类(Viral Proteins)

DOI 10.1016/j.celrep.2020.107586

PMID 32348767

发布时间 2021-05-13

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