首页> Journal of chromatography. A> Fragment-based Design of Zwitterionic, Strong Cation- and Weak Anion-Exchange Type Mixed-mode Liquid Chromatography Ligands and their Chromatographic Exploration.

Fragment-based Design of Zwitterionic, Strong Cation- and Weak Anion-Exchange Type Mixed-mode Liquid Chromatography Ligands and their Chromatographic Exploration.

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第一作者： Martina,Ferri

第一单位： Institute of Pharmaceutical Sciences, Pharmaceutical (Bio-)Analysis, University of Tübingen, Auf der Morgenstelle 8, 72076 Tübingen, Germany; Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo 1, 06123 Perugia, Italy.

作者： Martina,Ferri ^[1] ; Stefanie,Bäurer ^[2] ; Andrea,Carotti ^[3] ; Marc,Wolter ^[2] ; Belal,Alshaar ^[2] ; Johannes,Theiner ^[4] ; Tohru,Ikegami ^[5] ; Caroline,West ^[6] ; Michael,Lämmerhofer ^[7]

作者单位： Institute of Pharmaceutical Sciences, Pharmaceutical (Bio-)Analysis, University of Tübingen, Auf der Morgenstelle 8, 72076 Tübingen, Germany; Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo 1, 06123 Perugia, Italy. ^[1] Institute of Pharmaceutical Sciences, Pharmaceutical (Bio-)Analysis, University of Tübingen, Auf der Morgenstelle 8, 72076 Tübingen, Germany. ^[2] Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo 1, 06123 Perugia, Italy. ^[3] "Mikroanalytisches Laboratorium", University of Vienna, Währinger Strasse 42, 1090, Vienna, Austria. ^[4] Institute of Pharmaceutical Sciences, Pharmaceutical (Bio-)Analysis, University of Tübingen, Auf der Morgenstelle 8, 72076 Tübingen, Germany; Department of Materials Synthesis, Faculty of Molecular Chemistry and Engineering, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan. ^[5] University of Orléans, Institute of Organic and Analytical Chemistry, CNRS UMR 7311, Rue de Chartres BP 6759, 45067 Orléans, France. ^[6] Institute of Pharmaceutical Sciences, Pharmaceutical (Bio-)Analysis, University of Tübingen, Auf der Morgenstelle 8, 72076 Tübingen, Germany. Electronic address: michael.laemmerhofer@uni-tuebingen.de. ^[7]

关键词 Mixed-mode chromatography hydrophilic interaction chromatography (HILIC)mixed-mode anion-exchangers mixed-mode cation-exchangers molecular dynamics simulation zwitterionic mixed-mode ion-exchangers

主题词阴离子(Anions);阳离子(Cations);色谱法, 离子交换(Chromatography, Ion Exchange);电泳, 毛细管(Electrophoresis, Capillary);亲水和疏水相互作用(Hydrophobic and Hydrophilic Interactions);配体(Ligands);分子动力学模拟(Molecular Dynamics Simulation)

DOI 10.1016/j.chroma.2020.461075

PMID 32354558

发布时间 2020-07-21

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