Syntheses and Structure-Activity Relationships in Antibacterial Activity against Clostridium difficile and XBP1 Activation Property of 13-[(N-Alkylamino)methyl]-8-oxodihydrocoptisines.

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作者： Jing,Li ^[1] ; Hai-Jing,Zhang ^[1] ; An-Jun,Deng ^[1] ; Zhi-Hong,Li ^[1] ; Ya-Ling,Xing ^[2] ; Lian-Qiu,Wu ^[1] ; Hai-Lin,Qin ^[1]

作者单位： State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, P. R. China. ^[1] Beijing Institute of Radiation Medicine, Beijing, 100850, P. R. China. ^[2]

关键词 XBP1-activating activity antibacterial activity quaternary coptisine chloride structure modification structure-activity relationships

主题词抗菌药(Anti-Bacterial Agents);剂量效应关系, 药物(Dose-Response Relationship, Drug);微生物敏感性试验(Microbial Sensitivity Tests);分子结构(Molecular Structure);构效关系(Structure-Activity Relationship)

DOI 10.1002/cbdv.202000265

PMID 32364669

发布时间 2021-05-25

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