YTHDF2 promotes the liver cancer stem cell phenotype and cancer metastasis by regulating OCT4 expression via m6A RNA methylation.
第一作者:
Chuanzhao,Zhang
第一单位:
Department of General Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, School of Medicine, South China University of Technology, Guangzhou, 510080, China. 641703837@qq.com.
作者:
主题词
腺苷(Adenosine);动物(Animals);癌, 肝细胞(Carcinoma, Hepatocellular);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);Hep G2细胞(Hep G2 Cells);人类(Humans);肝(Liver);肝肿瘤(Liver Neoplasms);男(雄)性(Male);甲基化(Methylation);小鼠(Mice);小鼠, 近交BALB C(Mice, Inbred BALB C);小鼠, 裸(Mice, Nude);肿瘤转移(Neoplasm Metastasis);肿瘤移植(Neoplasm Transplantation);肿瘤干细胞(Neoplastic Stem Cells);八聚体转录因子3(Octamer Transcription Factor-3);预后(Prognosis);RNA, 信使(RNA, Messenger);RNA结合蛋白质类(RNA-Binding Proteins);球形体, 细胞(Spheroids, Cellular);移植, 异种(Transplantation, Heterologous);肿瘤细胞, 培养的(Tumor Cells, Cultured)
DOI
10.1038/s41388-020-1303-7
PMID
32366907
发布时间
2021-08-06
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Oncogene
4507-4518页
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