EGFR Inhibitor Gefitinib Induces Cardiotoxicity through the Modulation of Cardiac PTEN/Akt/FoxO3a Pathway and Reactive Metabolites Formation: <i>In Vivo</i> and <i>in Vitro</i> Rat Studies.

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第一作者： Ali,Alhoshani

第一单位： Department of Pharmacology & Toxicology, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.

作者： Ali,Alhoshani ^[1] ; Fawaz E,Alanazi ^[1] ; Moureq R,Alotaibi ^[2] ; Mohamed W,Attwa ^[1] ; Adnan A,Kadi ^[3] ; Abdullah,Aldhfyan ^[4] ; Sabah,Akhtar ^[3] ; Shireen,Hourani ^[5] ; Abdelali,Agouni ^[6] ; Asad,Zeidan ^[6] ; Hesham M,Korashy ^[6]

作者单位： Department of Pharmacology & Toxicology, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia. ^[1] Security Forces Hospital Program, P.O. Box 3643, Riyadh 11481, Saudi Arabia. ^[2] Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia. ^[3] Students' University Hospital, Mansoura University, Mansoura 35516, Egypt. ^[4] Stem Cell & Tissue Re-Engineering, King Faisal Specialist Hospital and Research Center, Riyadh 11211, Saudi Arabia. ^[5] Department of Pharmaceutical Sciences, College of Pharmacy, QU Health, Qatar University, P.O. Box 2713, Doha, Qatar. ^[6] College of Medicine, QU Health, Qatar University, P.O. Box 2713, Doha, Qatar. ^[7]