换一批A method combining blue native polyacrylamide gel electrophoresis with liquid chromatography tandem-mass spectrometry to detect circulating immune complexes between therapeutic monoclonal antibodies and anti-drug antibodies in animals.
第一作者：
Kazuhiro,Kobayashi
第一单位：
Pharmacokinetics Research Laboratories, Translational Research Unit, R&D Division, Kyowa Kirin Co. Ltd., 1188 Shimotogari, Nagaizumi-cho, Sunto-gun, Shizuoka, 411-8731, Japan. Electronic address: kazuhiro.kobayashi.sz@kyowakirin.com.
作者：
医学主题词
动物(Animals);抗体(Antibodies);抗体, 单克隆(Antibodies, Monoclonal);抗原抗体复合物(Antigen-Antibody Complex);色谱法, 液相(Chromatography, Liquid);女(雌)性(Female);直鼻猴亚目(Haplorhini);人类(Humans);免疫球蛋白G(Immunoglobulin G);小鼠(Mice);肽类(Peptides);串联质谱法(Tandem Mass Spectrometry)
DOI
10.1016/j.jpba.2020.113329
PMID
32371323
发布时间
2021-05-04
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