The Parkinson's Disease Protein LRRK2 Interacts with the GARP Complex to Promote Retrograde Transport to the trans-Golgi Network.

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第一作者： Alexandra,Beilina

第一单位： Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20814, USA.

作者： Alexandra,Beilina ^[1] ; Luis,Bonet-Ponce ^[1] ; Ravindran,Kumaran ^[1] ; Jennifer J,Kordich ^[2] ; Morié,Ishida ^[3] ; Adamantios,Mamais ^[1] ; Alice,Kaganovich ^[1] ; Sara,Saez-Atienzar ^[1] ; David C,Gershlick ^[3] ; Dorien A,Roosen ^[4] ; Laura,Pellegrini ^[5] ; Vlad,Malkov ^[6] ; Matthew J,Fell ^[6] ; Kirsten,Harvey ^[7] ; Juan S,Bonifacino ^[3] ; Darren J,Moore ^[2] ; Mark R,Cookson ^[8]

作者单位： Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20814, USA. ^[1] Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, MI 49503, USA. ^[2] Cell Biology and Neurobiology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20814, USA. ^[3] Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20814, USA; School of Pharmacy, University of Reading, Whiteknights, Reading, RG6 6AP, UK. ^[4] Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20814, USA; Department of Pharmacology, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London, WC1N 1AX, UK. ^[5] Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, MA 02115, USA. ^[6] Department of Pharmacology, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London, WC1N 1AX, UK. ^[7] Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20814, USA. Electronic address: cookson@mail.nih.gov. ^[8]

关键词 Leucine-rich repeat kinase 2 RAB29 RAB7L1 VPS52 endosome lysosome membrane trafficking neurodegeneration neurodegenerative disease neuroscience