Polymethoxyflavones from Gardenia oudiepe (Rubiaceae) induce cytoskeleton disruption-mediated apoptosis and sensitize BRAF-mutated melanoma cells to chemotherapy.

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第一作者： Raimundo,Gonçalves de Oliveira-Júnior

第一单位： LIENSs UMRi CNRS 7266, La Rochelle Université, 17042, La Rochelle, France. Electronic address: rgonca01@univ-lr.fr.

作者： Raimundo,Gonçalves de Oliveira-Júnior ^[1] ; Nolwenn,Marcoult-Fréville ^[2] ; Grégoire,Prunier ^[2] ; Laureen,Beaugeard ^[2] ; Edilson,Beserra de Alencar Filho ^[3] ; Eduard David,Simões Mourão ^[3] ; Sylvie,Michel ^[4] ; Lucindo José,Quintans-Júnior ^[5] ; Jackson Roberto,Guedes da Silva Almeida ^[6] ; Raphaël,Grougnet ^[4] ; Laurent,Picot ^[2]

作者单位： LIENSs UMRi CNRS 7266, La Rochelle Université, 17042, La Rochelle, France. Electronic address: rgonca01@univ-lr.fr. ^[1] LIENSs UMRi CNRS 7266, La Rochelle Université, 17042, La Rochelle, France. ^[2] Department of Pharmacy, Universidade Federal do Vale do São Francisco, 56304-205, Petrolina, Pernambuco, Brazil. ^[3] Equipe Produits Naturels, Analyse, Synthèse, UMR CNRS 8038, Université Paris Descartes, 75006, Paris, France. ^[4] LANEF, Universidade Federal de Sergipe, 49100-000, São Cristóvão, Sergipe, Brazil. ^[5] NEPLAME, Universidade Federal do Vale do São Francisco, 56304-205, Petrolina, Pernambuco, Brazil. ^[6]

关键词 Apoptosis Cancer Cytoskeleton Flavonoids Melanoma Multidrug resistance